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Metformin acts in the gut and induces gut-liver crosstalk.
Tobar N, Rocha GZ, Santos A, Guadagnini D, Assalin HB, Camargo JA, Gonçalves AESS, Pallis FR, Oliveira AG, Rocco SA, Neto RM, de Sousa IL, Alborghetti MR, Sforça ML, Rodrigues PB, Ludwig RG, Vanzela EC, Brunetto SQ, Boer PA, Gontijo JAR, Geloneze B, Carvalho CRO, Prada PO, Folli F, Curi R, Mori MA, Vinolo MAR, Ramos CD, Franchini KG, Tormena CF, Saad MJA. Tobar N, et al. Among authors: prada po. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2211933120. doi: 10.1073/pnas.2211933120. Epub 2023 Jan 19. Proc Natl Acad Sci U S A. 2023. PMID: 36656866 Free PMC article.
IL-6 and IL-10 anti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKbeta and ER stress inhibition.
Ropelle ER, Flores MB, Cintra DE, Rocha GZ, Pauli JR, Morari J, de Souza CT, Moraes JC, Prada PO, Guadagnini D, Marin RM, Oliveira AG, Augusto TM, Carvalho HF, Velloso LA, Saad MJ, Carvalheira JB. Ropelle ER, et al. Among authors: prada po. PLoS Biol. 2010 Aug 24;8(8):e1000465. doi: 10.1371/journal.pbio.1000465. PLoS Biol. 2010. PMID: 20808781 Free PMC article. Retracted.
Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice.
Caricilli AM, Picardi PK, de Abreu LL, Ueno M, Prada PO, Ropelle ER, Hirabara SM, Castoldi Â, Vieira P, Camara NO, Curi R, Carvalheira JB, Saad MJ. Caricilli AM, et al. Among authors: prada po. PLoS Biol. 2011 Dec;9(12):e1001212. doi: 10.1371/journal.pbio.1001212. Epub 2011 Dec 6. PLoS Biol. 2011. PMID: 22162948 Free PMC article. Retracted.
Comment on: Ramos-Zavala et al. Effect of diacerein on insulin secretion and metabolic control in drug-naïve patients with type 2 diabetes: a randomized clinical trial. Diabetes Care 2011;34:1591-1594.
Tobar N, Oliveira AG, Guadagnini D, Bagarolli RA, Rocha GZ, Araujo TG, Prada PO, Saad MJ. Tobar N, et al. Among authors: prada po. Diabetes Care. 2012 Feb;35(2):e13; author reply e14. doi: 10.2337/dc11-1856. Diabetes Care. 2012. PMID: 22275450 Free PMC article. No abstract available.
66 results