Pozzi C - Search Results

1

Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates.

Legru A, Verdirosa F, Vo-Hoang Y, Tassone G, Vascon F, Thomas CA, Sannio F, Corsica G, Benvenuti M, Feller G, Coulon R, Marcoccia F, Devente SR, Bouajila E, Piveteau C, Leroux F, Deprez-Poulain R, Deprez B, Licznar-Fajardo P, Crowder MW, Cendron L, Pozzi C, Mangani S, Docquier JD, Hernandez JF, Gavara L. Legru A, et al. Among authors: pozzi c. J Med Chem. 2022 Dec 22;65(24):16392-16419. doi: 10.1021/acs.jmedchem.2c01257. Epub 2022 Nov 30. J Med Chem. 2022. PMID: 36450011 Free article.

2

Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.

Mangani S, Cancian L, Leone R, Pozzi C, Lazzari S, Luciani R, Ferrari S, Costi MP. Mangani S, et al. Among authors: pozzi c. J Med Chem. 2011 Aug 11;54(15):5454-67. doi: 10.1021/jm2005018. Epub 2011 Jul 12. J Med Chem. 2011. PMID: 21696158

3

Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design.

De Luca F, Benvenuti M, Carboni F, Pozzi C, Rossolini GM, Mangani S, Docquier JD. De Luca F, et al. Among authors: pozzi c. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18424-9. doi: 10.1073/pnas.1110530108. Epub 2011 Oct 31. Proc Natl Acad Sci U S A. 2011. PMID: 22042844 Free PMC article.

4

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

Pozzi C, Ferrari S, Cortesi D, Luciani R, Stroud RM, Catalano A, Costi MP, Mangani S. Pozzi C, et al. Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1232-41. doi: 10.1107/S0907444912026236. Epub 2012 Aug 18. Acta Crystallogr D Biol Crystallogr. 2012. PMID: 22948925 Free PMC article.

5

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.

Ferrari S, Calò S, Leone R, Luciani R, Costantino L, Sammak S, Di Pisa F, Pozzi C, Mangani S, Costi MP. Ferrari S, et al. Among authors: pozzi c. J Med Chem. 2013 Nov 27;56(22):9356-60. doi: 10.1021/jm4014086. Epub 2013 Nov 13. J Med Chem. 2013. PMID: 24147825

6

Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative.

Tondi D, Venturelli A, Bonnet R, Pozzi C, Shoichet BK, Costi MP. Tondi D, et al. Among authors: pozzi c. J Med Chem. 2014 Jun 26;57(12):5449-58. doi: 10.1021/jm5006572. Epub 2014 Jun 16. J Med Chem. 2014. PMID: 24882105 Free PMC article.

7

Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.

Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC. Salo-Ahen OM, et al. Among authors: pozzi c. J Med Chem. 2015 Apr 23;58(8):3572-81. doi: 10.1021/acs.jmedchem.5b00137. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25798950 Free PMC article.

8

Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.

Pozzi C, Di Pisa F, Lalli D, Rosa C, Theil E, Turano P, Mangani S. Pozzi C, et al. Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):941-53. doi: 10.1107/S1399004715002333. Epub 2015 Mar 27. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 25849404 Free PMC article.

9

The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.

DiPisa F, Pozzi C, Benvenuti M, Andreini M, Marconi G, Mangani S. DiPisa F, et al. Among authors: pozzi c. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):986-92. doi: 10.1107/S2053230X15010389. Epub 2015 Jul 28. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26249687 Free PMC article.

10

Iron binding to human heavy-chain ferritin.

Pozzi C, Di Pisa F, Bernacchioni C, Ciambellotti S, Turano P, Mangani S. Pozzi C, et al. Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1909-20. doi: 10.1107/S1399004715013073. Epub 2015 Aug 25. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26327381

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