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Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators.
Bioorg Med Chem Lett. 2022 Apr 1;61:128607. doi: 10.1016/j.bmcl.2022.128607. Epub 2022 Feb 3.
Bioorg Med Chem Lett. 2022.
PMID: 35123006
Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease.
Brice NL, Schiffer HH, Monenschein H, Mulligan VJ, Page K, Powell J, Xu X, Cheung T, Burley JR, Sun H, Dickson L, Murphy ST, Kaushal N, Sheardown S, Lawrence J, Chen Y, Bartkowski D, Kanta A, Russo J, Hosea N, Dawson LA, Hitchcock SH, Carlton MB.
Brice NL, et al.
J Pharmacol Exp Ther. 2021 Jun;377(3):407-416. doi: 10.1124/jpet.120.000438. Epub 2021 Apr 1.
J Pharmacol Exp Ther. 2021.
PMID: 33795395
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Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome.
Ossola B, Rifat A, Rowland A, Hunter H, Drinkall S, Bender C, Hamlischer M, Teall M, Burley R, Barker DF, Cadwalladr D, Dickson L, Lawrence JMK, Harvey JRM, Lizio M, Xu X, Kavanagh E, Cheung T, Sheardown S, Lawrence CB, Harte M, Brough D, Madry C, Matthews K, Doyle K, Page K, Powell J, Brice NL, Bürli RW, Carlton MB, Dawson LA.
Ossola B, et al.
Neuropharmacology. 2023 Feb 15;224:109330. doi: 10.1016/j.neuropharm.2022.109330. Epub 2022 Nov 12.
Neuropharmacology. 2023.
PMID: 36375694
Free PMC article.
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Discovery and Characterization of Novel CNS-Penetrant GPR55 Agonists.
Hewer RC, Christie LA, Doyle KJ, Xu X, Roberts MJ, Dickson L, Cheung T, Cadwalladr DH, Pickford P, Teall M, Powell JAC, Sheardown S, Narayana L, Brice NL, Dawson LA, Carlton M, Bürli RW.
Hewer RC, et al. Among authors: powell jac.
J Med Chem. 2023 Sep 28;66(18):12858-12876. doi: 10.1021/acs.jmedchem.3c00784. Epub 2023 Sep 14.
J Med Chem. 2023.
PMID: 37708305
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GO2MSIG, an automated GO based multi-species gene set generator for gene set enrichment analysis.
Powell JA.
Powell JA.
BMC Bioinformatics. 2014 May 17;15:146. doi: 10.1186/1471-2105-15-146.
BMC Bioinformatics. 2014.
PMID: 24884810
Free PMC article.
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Construction of Rhodococcus random mutagenesis libraries using Tn5 transposition complexes.
Fernandes PJ, Powell JAC, Archer JAC.
Fernandes PJ, et al. Among authors: powell jac.
Microbiology (Reading). 2001 Sep;147(Pt 9):2529-2536. doi: 10.1099/00221287-147-9-2529.
Microbiology (Reading). 2001.
PMID: 11535792
Free article.
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