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Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.
Ding J, Gumpena R, Boily MO, Caron A, Chong O, Cox JH, Dumais V, Gaudreault S, Graff AH, King A, Knight J, Oballa R, Surendradoss J, Tang T, Wu J, Lowther WT, Powell DA. Ding J, et al. Among authors: powell da. ACS Med Chem Lett. 2021 May 20;12(7):1116-1123. doi: 10.1021/acsmedchemlett.1c00196. eCollection 2021 Jul 8. ACS Med Chem Lett. 2021. PMID: 34267881 Free PMC article.
Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors.
Isabel E, Powell DA, Black WC, Chan CC, Crane S, Gordon R, Guay J, Guiral S, Huang Z, Robichaud J, Skorey K, Tawa P, Xu L, Zhang L, Oballa R. Isabel E, et al. Among authors: powell da. Bioorg Med Chem Lett. 2011 Jan 1;21(1):479-83. doi: 10.1016/j.bmcl.2010.10.107. Epub 2010 Oct 26. Bioorg Med Chem Lett. 2011. PMID: 21074991
Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.
Oballa RM, Belair L, Black WC, Bleasby K, Chan CC, Desroches C, Du X, Gordon R, Guay J, Guiral S, Hafey MJ, Hamelin E, Huang Z, Kennedy B, Lachance N, Landry F, Li CS, Mancini J, Normandin D, Pocai A, Powell DA, Ramtohul YK, Skorey K, Sørensen D, Sturkenboom W, Styhler A, Waddleton DM, Wang H, Wong S, Xu L, Zhang L. Oballa RM, et al. Among authors: powell da. J Med Chem. 2011 Jul 28;54(14):5082-96. doi: 10.1021/jm200319u. Epub 2011 Jun 28. J Med Chem. 2011. PMID: 21661758
Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.
Powell DA, Black WC, Bleasby K, Chan CC, Deschenes D, Gagnon M, Gordon R, Guay J, Guiral S, Hafey MJ, Huang Z, Isabel E, Leblanc Y, Styhler A, Xu LJ, Zhang L, Oballa RM. Powell DA, et al. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7281-6. doi: 10.1016/j.bmcl.2011.10.040. Epub 2011 Oct 18. Bioorg Med Chem Lett. 2011. PMID: 22047692
Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.
Lachance N, Gareau Y, Guiral S, Huang Z, Isabel E, Leclerc JP, Léger S, Martins E, Nadeau C, Oballa RM, Ouellet SG, Powell DA, Ramtohul YK, Tranmer GK, Trinh T, Wang H, Zhang L. Lachance N, et al. Among authors: powell da. Bioorg Med Chem Lett. 2012 Jan 15;22(2):980-4. doi: 10.1016/j.bmcl.2011.12.002. Epub 2011 Dec 8. Bioorg Med Chem Lett. 2012. PMID: 22209206
Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets.
Popadynec M, Baradaran-Heravi A, Alford B, Cameron SA, Clinch K, Mason JM, Rendle PM, Zubkova OV, Gan Z, Liu H, Rebollo O, Whitfield DM, Yan F, Roberge M, Powell DA. Popadynec M, et al. Among authors: powell da. ACS Med Chem Lett. 2021 Aug 9;12(9):1486-1492. doi: 10.1021/acsmedchemlett.1c00349. eCollection 2021 Sep 9. ACS Med Chem Lett. 2021. PMID: 34531957 Free PMC article.
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
Bukhtiyarova M, Cook EM, Hancock PJ, Hruza AW, Shaw AW, Adam GC, Barnard RJO, McKenna PM, Holloway MK, Bell IM, Carroll S, Cornella-Taracido I, Cox CD, Kutchukian PS, Powell DA, Strickland C, Trotter BW, Tudor M, Wolkenberg S, Li J, Tellers DM. Bukhtiyarova M, et al. Among authors: powell da. ACS Med Chem Lett. 2020 Dec 23;12(1):99-106. doi: 10.1021/acsmedchemlett.0c00551. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488970 Free PMC article.
327 results