Pouysségur J - Search Results

1

Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses.

Daher B, Parks SK, Durivault J, Cormerais Y, Baidarjad H, Tambutte E, Pouysségur J, Vučetić M. Daher B, et al. Among authors: pouyssegur j. Cancer Res. 2019 Aug 1;79(15):3877-3890. doi: 10.1158/0008-5472.CAN-18-3855. Epub 2019 Jun 7. Cancer Res. 2019. PMID: 31175120

2

The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.

Dayan F, Roux D, Brahimi-Horn MC, Pouyssegur J, Mazure NM. Dayan F, et al. Among authors: pouyssegur j. Cancer Res. 2006 Apr 1;66(7):3688-98. doi: 10.1158/0008-5472.CAN-05-4564. Cancer Res. 2006. PMID: 16585195

3

Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

Chiche J, Ilc K, Laferrière J, Trottier E, Dayan F, Mazure NM, Brahimi-Horn MC, Pouysségur J. Chiche J, et al. Among authors: pouyssegur j. Cancer Res. 2009 Jan 1;69(1):358-68. doi: 10.1158/0008-5472.CAN-08-2470. Cancer Res. 2009. PMID: 19118021

4

pH control mechanisms of tumor survival and growth.

Parks SK, Chiche J, Pouyssegur J. Parks SK, et al. Among authors: pouyssegur j. J Cell Physiol. 2011 Feb;226(2):299-308. doi: 10.1002/jcp.22400. J Cell Physiol. 2011. PMID: 20857482 Review.

5

The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth.

Pez F, Dayan F, Durivault J, Kaniewski B, Aimond G, Le Provost GS, Deux B, Clézardin P, Sommer P, Pouysségur J, Reynaud C. Pez F, et al. Among authors: pouyssegur j. Cancer Res. 2011 Mar 1;71(5):1647-57. doi: 10.1158/0008-5472.CAN-10-1516. Epub 2011 Jan 14. Cancer Res. 2011. PMID: 21239473

6

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

Chiche J, Le Fur Y, Vilmen C, Frassineti F, Daniel L, Halestrap AP, Cozzone PJ, Pouysségur J, Lutz NW. Chiche J, et al. Among authors: pouyssegur j. Int J Cancer. 2012 Apr 1;130(7):1511-20. doi: 10.1002/ijc.26125. Epub 2011 May 30. Int J Cancer. 2012. PMID: 21484790 Free article.

7

The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis.

Pelletier J, Dayan F, Durivault J, Ilc K, Pécou E, Pouysségur J, Mazure NM. Pelletier J, et al. Among authors: pouyssegur j. Oncogene. 2012 Jun 14;31(24):2989-3001. doi: 10.1038/onc.2011.471. Epub 2011 Oct 17. Oncogene. 2012. PMID: 22002313

8

Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance.

Brahimi-Horn MC, Ben-Hail D, Ilie M, Gounon P, Rouleau M, Hofman V, Doyen J, Mari B, Shoshan-Barmatz V, Hofman P, Pouysségur J, Mazure NM. Brahimi-Horn MC, et al. Among authors: pouyssegur j. Cancer Res. 2012 Apr 15;72(8):2140-50. doi: 10.1158/0008-5472.CAN-11-3940. Epub 2012 Mar 2. Cancer Res. 2012. PMID: 22389449

9

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis.

Doyen J, Parks SK, Marcié S, Pouysségur J, Chiche J. Doyen J, et al. Among authors: pouyssegur j. Front Oncol. 2013 Jan 7;2:199. doi: 10.3389/fonc.2012.00199. eCollection 2012. Front Oncol. 2013. PMID: 23316475 Free PMC article.

10

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels.

Parks SK, Mazure NM, Counillon L, Pouysségur J. Parks SK, et al. Among authors: pouyssegur j. J Cell Physiol. 2013 Sep;228(9):1854-62. doi: 10.1002/jcp.24346. J Cell Physiol. 2013. PMID: 23459996

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