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NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner.
Waqas FH, Shehata M, Elgaher WAM, Lacour A, Kurmasheva N, Begnini F, Kiib AE, Dahlmann J, Chen C, Pavlou A, Poulsen TB, Merkert S, Martin U, Olmer R, Olagnier D, Hirsch AKH, Pleschka S, Pessler F. Waqas FH, et al. Among authors: poulsen tb. PLoS Pathog. 2023 Jul 17;19(7):e1011506. doi: 10.1371/journal.ppat.1011506. eCollection 2023 Jul. PLoS Pathog. 2023. PMID: 37459366 Free PMC article.
α-Lactam Electrophiles for Covalent Chemical Biology.
Mahía A, Kiib AE, Nisavic M, Svenningsen EB, Palmfeldt J, Poulsen TB. Mahía A, et al. Among authors: poulsen tb. Angew Chem Int Ed Engl. 2023 Jun 26;62(26):e202304142. doi: 10.1002/anie.202304142. Epub 2023 May 15. Angew Chem Int Ed Engl. 2023. PMID: 37114559
The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21.
Svenningsen EB, Ottosen RN, Jørgensen KH, Nisavic M, Larsen CK, Hansen BK, Wang Y, Lindorff-Larsen K, Tørring T, Hacker SM, Palmfeldt J, Poulsen TB. Svenningsen EB, et al. Among authors: poulsen tb. RSC Chem Biol. 2022 Sep 7;3(10):1216-1229. doi: 10.1039/d2cb00161f. eCollection 2022 Oct 5. RSC Chem Biol. 2022. PMID: 36320884 Free PMC article.
Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity.
Andersen FD, Pedersen KD, Wilkens Juhl D, Mygind T, Chopin P, B Svenningsen E, Poulsen TB, Braad Lund M, Schramm A, Gotfredsen CH, Tørring T. Andersen FD, et al. Among authors: poulsen tb. J Nat Prod. 2022 Jun 24;85(6):1514-1521. doi: 10.1021/acs.jnatprod.2c00065. Epub 2022 Jun 15. J Nat Prod. 2022. PMID: 35748039 Review.
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity.
Casares L, Moreno R, Ali KX, Higgins M, Dayalan Naidu S, Neill G, Cassin L, Kiib AE, Svenningsen EB, Minassi A, Honda T, Poulsen TB, Wiel C, Sayin VI, Dinkova-Kostova AT, Olagnier D, de la Vega L. Casares L, et al. Among authors: poulsen tb. Redox Biol. 2022 May;51:102291. doi: 10.1016/j.redox.2022.102291. Epub 2022 Mar 17. Redox Biol. 2022. PMID: 35313207 Free PMC article.
72 results