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Triple MAPK inhibition salvaged a relapsed post-BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E subclonal mutation.
Elnaggar M, Agte S, Restrepo P, Ram M, Melnekoff D, Adamopoulos C, Stevens MM, Kappes K, Leshchenko V, Verina D, Jagannath S, Poulikakos PI, Parekh S, Laganà A. Elnaggar M, et al. Among authors: poulikakos pi. J Hematol Oncol. 2022 Aug 17;15(1):109. doi: 10.1186/s13045-022-01330-3. J Hematol Oncol. 2022. PMID: 35978321 Free PMC article.
Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis.
Chakraborty R, Burke TM, Hampton OA, Zinn DJ, Lim KP, Abhyankar H, Scull B, Kumar V, Kakkar N, Wheeler DA, Roy A, Poulikakos PI, Merad M, McClain KL, Parsons DW, Allen CE. Chakraborty R, et al. Among authors: poulikakos pi. Blood. 2016 Nov 24;128(21):2533-2537. doi: 10.1182/blood-2016-08-733790. Epub 2016 Oct 11. Blood. 2016. PMID: 27729324 Free PMC article.
Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling.
Adamopoulos C, Ahmed TA, Tucker MR, Ung PMU, Xiao M, Karoulia Z, Amabile A, Wu X, Aaronson SA, Ang C, Rebecca VW, Brown BD, Schlessinger A, Herlyn M, Wang Q, Shaw DE, Poulikakos PI. Adamopoulos C, et al. Among authors: poulikakos pi. Cancer Discov. 2021 Jul;11(7):1716-1735. doi: 10.1158/2159-8290.CD-20-1351. Epub 2021 Feb 10. Cancer Discov. 2021. PMID: 33568355 Free PMC article.
Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders.
Wu X, Yang X, Xiong Y, Li R, Ito T, Ahmed TA, Karoulia Z, Adamopoulos C, Wang H, Wang L, Xie L, Liu J, Ueberheide B, Aaronson SA, Chen X, Buchanan SG, Sellers WR, Jin J, Poulikakos PI. Wu X, et al. Among authors: poulikakos pi. Nat Cancer. 2021 Apr;2(4):429-443. doi: 10.1038/s43018-021-00174-z. Epub 2021 Mar 1. Nat Cancer. 2021. PMID: 34568836 Free PMC article.
CDK4: a master regulator of the cell cycle and its role in cancer.
Baker SJ, Poulikakos PI, Irie HY, Parekh S, Reddy EP. Baker SJ, et al. Among authors: poulikakos pi. Genes Cancer. 2022 Aug 25;13:21-45. doi: 10.18632/genesandcancer.221. eCollection 2022. Genes Cancer. 2022. PMID: 36051751 Free PMC article. Review.
RAF and MEK Inhibitors in Non-Small Cell Lung Cancer.
Adamopoulos C, Papavassiliou KA, Poulikakos PI, Papavassiliou AG. Adamopoulos C, et al. Among authors: poulikakos pi. Int J Mol Sci. 2024 Apr 24;25(9):4633. doi: 10.3390/ijms25094633. Int J Mol Sci. 2024. PMID: 38731852 Free PMC article. Review.
44 results