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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
Ren AA, Snellings DA, Su YS, Hong CC, Castro M, Tang AT, Detter MR, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman MM, Müller-Fielitz H, Chen M, Mericko P, Yang J, Sung DC, Lawton MT, Ruppert JM, Schwaninger M, Körbelin J, Potente M, Awad IA, Marchuk DA, Kahn ML. Ren AA, et al. Among authors: potente m. Nature. 2021 Jun;594(7862):271-276. doi: 10.1038/s41586-021-03562-8. Epub 2021 Apr 28. Nature. 2021. PMID: 33910229 Free PMC article.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MHH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M. Guarani V, et al. Among authors: potente m. Nature. 2011 May 12;473(7346):234-8. doi: 10.1038/nature09917. Epub 2011 Apr 17. Nature. 2011. PMID: 21499261 Free PMC article.
FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, Zimmermann B, Aspalter IM, Franco CA, Boettger T, Braun T, Fruttiger M, Rajewsky K, Keller C, Brüning JC, Gerhardt H, Carmeliet P, Potente M. Wilhelm K, et al. Among authors: potente m. Nature. 2016 Jan 14;529(7585):216-20. doi: 10.1038/nature16498. Epub 2016 Jan 6. Nature. 2016. PMID: 26735015 Free PMC article.
Arterialization requires the timely suppression of cell growth.
Luo W, Garcia-Gonzalez I, Fernández-Chacón M, Casquero-Garcia V, Sanchez-Muñoz MS, Mühleder S, Garcia-Ortega L, Andrade J, Potente M, Benedito R. Luo W, et al. Among authors: potente m. Nature. 2021 Jan;589(7842):437-441. doi: 10.1038/s41586-020-3018-x. Epub 2020 Dec 9. Nature. 2021. PMID: 33299176 Free PMC article.
Control of endothelial quiescence by FOXO-regulated metabolites.
Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M. Andrade J, et al. Among authors: potente m. Nat Cell Biol. 2021 Apr;23(4):413-423. doi: 10.1038/s41556-021-00637-6. Epub 2021 Apr 1. Nat Cell Biol. 2021. PMID: 33795871 Free PMC article.
Post-myocardial infarction heart failure dysregulates the bone vascular niche.
Hoffmann J, Luxán G, Abplanalp WT, Glaser SF, Rasper T, Fischer A, Muhly-Reinholz M, Potente M, Assmus B, John D, Zeiher AM, Dimmeler S. Hoffmann J, et al. Among authors: potente m. Nat Commun. 2021 Jun 25;12(1):3964. doi: 10.1038/s41467-021-24045-4. Nat Commun. 2021. PMID: 34172720 Free PMC article.
The blood-brain barrier-a metabolic ecosystem.
Castro M, Potente M. Castro M, et al. Among authors: potente m. EMBO J. 2022 May 2;41(9):e111189. doi: 10.15252/embj.2022111189. Epub 2022 Apr 19. EMBO J. 2022. PMID: 35437788 Free PMC article.
A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.
Ong YT, Andrade J, Armbruster M, Shi C, Castro M, Costa ASH, Sugino T, Eelen G, Zimmermann B, Wilhelm K, Lim J, Watanabe S, Guenther S, Schneider A, Zanconato F, Kaulich M, Pan D, Braun T, Gerhardt H, Efeyan A, Carmeliet P, Piccolo S, Grosso AR, Potente M. Ong YT, et al. Among authors: potente m. Nat Metab. 2022 Jun;4(6):672-682. doi: 10.1038/s42255-022-00584-y. Epub 2022 Jun 20. Nat Metab. 2022. PMID: 35726026 Free PMC article.
58 results