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5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.
Vymětalová L, Havlíček L, Šturc A, Skrášková Z, Jorda R, Pospíšil T, Strnad M, Kryštof V. Vymětalová L, et al. Among authors: pospisil t. Eur J Med Chem. 2016 Mar 3;110:291-301. doi: 10.1016/j.ejmech.2016.01.011. Epub 2016 Jan 18. Eur J Med Chem. 2016. PMID: 26851505
Stable isotope dilution ultra-high performance liquid chromatography-tandem mass spectrometry quantitative profiling of tryptophan-related neuroactive substances in human serum and cerebrospinal fluid.
Hényková E, Vránová HP, Amakorová P, Pospíšil T, Žukauskaitė A, Vlčková M, Urbánek L, Novák O, Mareš J, Kaňovský P, Strnad M. Hényková E, et al. Among authors: pospisil t. J Chromatogr A. 2016 Mar 11;1437:145-157. doi: 10.1016/j.chroma.2016.02.009. Epub 2016 Feb 6. J Chromatogr A. 2016. PMID: 26879452
3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Jorda R, Havlíček L, Šturc A, Tušková D, Daumová L, Alam M, Škerlová J, Nekardová M, Peřina M, Pospíšil T, Široká J, Urbánek L, Pachl P, Řezáčová P, Strnad M, Klener P, Kryštof V. Jorda R, et al. Among authors: pospisil t. J Med Chem. 2019 May 9;62(9):4606-4623. doi: 10.1021/acs.jmedchem.9b00189. Epub 2019 Apr 17. J Med Chem. 2019. PMID: 30943029
6-Substituted purines as ROCK inhibitors with anti-metastatic activity.
Voller J, Zahajská L, Plíhalová L, Jeřábková J, Burget D, Pataki AC, Kryštof V, Zatloukal M, Brábek J, Rösel D, Mik V, Tkáč M, Pospíšil T, Gucký T, Doležal K, Strnad M. Voller J, et al. Among authors: pospisil t. Bioorg Chem. 2019 Sep;90:103005. doi: 10.1016/j.bioorg.2019.103005. Epub 2019 Jun 6. Bioorg Chem. 2019. PMID: 31271944
41 results