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Virus structure and structure-based antivirals.
Plavec Z, Pöhner I, Poso A, Butcher SJ. Plavec Z, et al. Among authors: poso a. Curr Opin Virol. 2021 Dec;51:16-24. doi: 10.1016/j.coviro.2021.09.005. Epub 2021 Sep 24. Curr Opin Virol. 2021. PMID: 34564030 Free PMC article. Review.
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Liu X, Huuskonen S, Laitinen T, Redchuk T, Bogacheva M, Salokas K, Pöhner I, Öhman T, Tonduru AK, Hassinen A, Gawriyski L, Keskitalo S, Vartiainen MK, Pietiäinen V, Poso A, Varjosalo M. Liu X, et al. Among authors: poso a. Mol Syst Biol. 2021 Nov;17(11):e10396. doi: 10.15252/msb.202110396. Mol Syst Biol. 2021. PMID: 34709727 Free PMC article.
Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection.
Asquith CR, Meli ML, Konstantinova LS, Laitinen T, Poso A, Rakitin OA, Hofmann-Lehmann R, Allenspach K, Hilton ST. Asquith CR, et al. Among authors: poso a. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1352-5. doi: 10.1016/j.bmcl.2014.12.047. Epub 2014 Dec 20. Bioorg Med Chem Lett. 2015. PMID: 25702849 Free article.
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination.
Pillaiyar T, Flury P, Krüger N, Su H, Schäkel L, Barbosa Da Silva E, Eppler O, Kronenberger T, Nie T, Luedtke S, Rocha C, Sylvester K, Petry MRI, McKerrow JH, Poso A, Pöhlmann S, Gütschow M, O'Donoghue AJ, Xu Y, Müller CE, Laufer SA. Pillaiyar T, et al. Among authors: poso a. J Med Chem. 2022 Jul 14;65(13):9376-9395. doi: 10.1021/acs.jmedchem.2c00636. Epub 2022 Jun 16. J Med Chem. 2022. PMID: 35709506
Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2.
Huhtiniemi T, Salo HS, Suuronen T, Poso A, Salminen A, Leppänen J, Jarho E, Lahtela-Kakkonen M. Huhtiniemi T, et al. Among authors: poso a. J Med Chem. 2011 Oct 13;54(19):6456-68. doi: 10.1021/jm200590k. Epub 2011 Sep 7. J Med Chem. 2011. PMID: 21895016
297 results