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Comparative and pharmacophore model for deacetylase SIRT1.
Huhtiniemi T, Wittekindt C, Laitinen T, Leppänen J, Salminen A, Poso A, Lahtela-Kakkonen M. Huhtiniemi T, et al. Among authors: poso a. J Comput Aided Mol Des. 2006 Sep;20(9):589-99. doi: 10.1007/s10822-006-9084-9. Epub 2006 Nov 11. J Comput Aided Mol Des. 2006. PMID: 17103016
Molecular dynamics simulations for human CAR inverse agonists.
Jyrkkärinne J, Küblbeck J, Pulkkinen J, Honkakoski P, Laatikainen R, Poso A, Laitinen T. Jyrkkärinne J, et al. Among authors: poso a. J Chem Inf Model. 2012 Feb 27;52(2):457-64. doi: 10.1021/ci200432k. Epub 2012 Jan 25. J Chem Inf Model. 2012. PMID: 22233089
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.
Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, Korhonen J, Navia-Paldanius D, Häyrinen J, Takabe P, Käsnänen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppänen S, Poso A, Nevalainen T, Laitinen JT. Aaltonen N, et al. Among authors: poso a. Chem Biol. 2013 Mar 21;20(3):379-90. doi: 10.1016/j.chembiol.2013.01.012. Chem Biol. 2013. PMID: 23521796
Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.
Patel JZ, Parkkari T, Laitinen T, Kaczor AA, Saario SM, Savinainen JR, Navia-Paldanius D, Cipriano M, Leppänen J, Koshevoy IO, Poso A, Fowler CJ, Laitinen JT, Nevalainen T. Patel JZ, et al. Among authors: poso a. J Med Chem. 2013 Nov 14;56(21):8484-96. doi: 10.1021/jm400923s. Epub 2013 Oct 22. J Med Chem. 2013. PMID: 24083878
Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.
Asquith CR, Meli ML, Konstantinova LS, Laitinen T, Peräkylä M, Poso A, Rakitin OA, Allenspach K, Hofmann-Lehmann R, Hilton ST. Asquith CR, et al. Among authors: poso a. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2640-4. doi: 10.1016/j.bmcl.2014.04.073. Epub 2014 Apr 26. Bioorg Med Chem Lett. 2014. PMID: 24813732
297 results