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Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport.
Chaussade C, Pirola L, Bonnafous S, Blondeau F, Brenz-Verca S, Tronchère H, Portis F, Rusconi S, Payrastre B, Laporte J, Van Obberghen E. Chaussade C, et al. Among authors: portis f. Mol Endocrinol. 2003 Dec;17(12):2448-60. doi: 10.1210/me.2003-0261. Epub 2003 Sep 18. Mol Endocrinol. 2003. PMID: 14500759
Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells.
Pirola L, Bonnafous S, Johnston AM, Chaussade C, Portis F, Van Obberghen E. Pirola L, et al. Among authors: portis f. J Biol Chem. 2003 May 2;278(18):15641-51. doi: 10.1074/jbc.M208984200. Epub 2003 Feb 18. J Biol Chem. 2003. PMID: 12594228 Free article.