Port A - Search Results

1

EST64454: a Highly Soluble σ₁ Receptor Antagonist Clinical Candidate for Pain Management.

Díaz JL, García M, Torrens A, Caamaño AM, Enjo J, Sicre C, Lorente A, Port A, Montero A, Yeste S, Álvarez I, Martín M, Maldonado R, de la Puente B, Vidal-Torres A, Cendán CM, Vela JM, Almansa C. Díaz JL, et al. Among authors: port a. J Med Chem. 2020 Dec 10;63(23):14979-14988. doi: 10.1021/acs.jmedchem.0c01575. Epub 2020 Nov 25. J Med Chem. 2020. PMID: 33237785

2

Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).

Díaz JL, Cuberes R, Berrocal J, Contijoch M, Christmann U, Fernández A, Port A, Holenz J, Buschmann H, Laggner C, Serafini MT, Burgueño J, Zamanillo D, Merlos M, Vela JM, Almansa C. Díaz JL, et al. Among authors: port a. J Med Chem. 2012 Oct 11;55(19):8211-24. doi: 10.1021/jm3007323. Epub 2012 Jul 27. J Med Chem. 2012. PMID: 22784008

3

Synthesis and structure-activity relationship study of a new series of selective σ(1) receptor ligands for the treatment of pain: 4-aminotriazoles.

Díaz JL, Christmann U, Fernández A, Torrens A, Port A, Pascual R, Álvarez I, Burgueño J, Monroy X, Montero A, Balada A, Vela JM, Almansa C. Díaz JL, et al. Among authors: port a. J Med Chem. 2015 Mar 12;58(5):2441-51. doi: 10.1021/jm501920g. Epub 2015 Feb 19. J Med Chem. 2015. PMID: 25658964

4

4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ₁ Receptor Antagonists for the Treatment of Pain.

García M, Virgili M, Alonso M, Alegret C, Fernández B, Port A, Pascual R, Monroy X, Vidal-Torres A, Serafini MT, Vela JM, Almansa C. García M, et al. Among authors: port a. J Med Chem. 2020 Mar 12;63(5):2434-2454. doi: 10.1021/acs.jmedchem.9b01256. Epub 2019 Dec 5. J Med Chem. 2020. PMID: 31743642 Free article.

5

Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter.

Díaz JL, Cuevas F, Pazos G, Álvarez-Bercedo P, Oliva AI, Sarmentero MÁ, Font D, Jiménez-Aquino A, Morón M, Port A, Pascual R, Dordal A, Portillo-Salido E, Reinoso RF, Vela JM, Almansa C. Díaz JL, et al. Among authors: port a. J Med Chem. 2021 Feb 25;64(4):2167-2185. doi: 10.1021/acs.jmedchem.0c01867. Epub 2021 Feb 16. J Med Chem. 2021. PMID: 33591743

6

A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists.

Dordal A, Lipkin M, Macritchie J, Mas J, Port A, Rose S, Salgado L, Savic V, Schmidt W, Serafini MT, Spearing W, Torrens A, Yeste S. Dordal A, et al. Among authors: port a. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3679-84. doi: 10.1016/j.bmcl.2005.05.103. Bioorg Med Chem Lett. 2005. PMID: 15982873

7

Synthesis of new benzoxazinone derivatives as neuropeptide Y5 antagonists for the treatment of obesity.

Torrens A, Mas J, Port A, Castrillo JA, Sanfeliu O, Guitart X, Dordal A, Romero G, Fisas MA, Sánchez E, Hernández E, Pérez P, Pérez R, Buschmann H. Torrens A, et al. Among authors: port a. J Med Chem. 2005 Mar 24;48(6):2080-92. doi: 10.1021/jm049599u. J Med Chem. 2005. PMID: 15771450

8

Critical comparison of shake-flask, potentiometric and chromatographic methods for lipophilicity evaluation (log P_o/w) of neutral, acidic, basic, amphoteric, and zwitterionic drugs.

Port A, Bordas M, Enrech R, Pascual R, Rosés M, Ràfols C, Subirats X, Bosch E. Port A, et al. Eur J Pharm Sci. 2018 Sep 15;122:331-340. doi: 10.1016/j.ejps.2018.07.010. Epub 2018 Jul 10. Eur J Pharm Sci. 2018. PMID: 30006180 Free article.

9

The contribution of the hydrogen bond acidity on the lipophilicity of drugs estimated from chromatographic measurements.

Pallicer JM, Pascual R, Port A, Rosés M, Ràfols C, Bosch E. Pallicer JM, et al. Among authors: port a. Eur J Pharm Sci. 2013 Feb 14;48(3):484-93. doi: 10.1016/j.ejps.2012.12.008. Epub 2012 Dec 20. Eur J Pharm Sci. 2013. PMID: 23262061

10

Extension of the liquid chromatography/quantitative structure-property relationship method to assess the lipophilicity of neutral, acidic, basic and amphotheric drugs.

Pallicer JM, Calvet C, Port A, Rosés M, Ràfols C, Bosch E. Pallicer JM, et al. Among authors: port a. J Chromatogr A. 2012 Jun 1;1240:113-22. doi: 10.1016/j.chroma.2012.03.089. Epub 2012 Apr 5. J Chromatogr A. 2012. PMID: 22537604

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