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DNA damage persistence as determinant of tumor sensitivity to the combination of Topo I inhibitors and telomere-targeting agents.
Biroccio A, Porru M, Rizzo A, Salvati E, D'Angelo C, Orlandi A, Passeri D, Franceschin M, Stevens MF, Gilson E, Beretta G, Zupi G, Pisano C, Zunino F, Leonetti C. Biroccio A, et al. Among authors: porru m. Clin Cancer Res. 2011 Apr 15;17(8):2227-36. doi: 10.1158/1078-0432.CCR-10-3033. Epub 2011 Feb 25. Clin Cancer Res. 2011. PMID: 21355072
Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.
Salvati E, Zizza P, Rizzo A, Iachettini S, Cingolani C, D'Angelo C, Porru M, Randazzo A, Pagano B, Novellino E, Pisanu ME, Stoppacciaro A, Spinella F, Bagnato A, Gilson E, Leonetti C, Biroccio A. Salvati E, et al. Among authors: porru m. Nucleic Acids Res. 2014 Mar;42(5):2945-57. doi: 10.1093/nar/gkt1289. Epub 2013 Dec 11. Nucleic Acids Res. 2014. PMID: 24335081 Free PMC article.
MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer.
Dinami R, Pompili L, Petti E, Porru M, D'Angelo C, Di Vito S, Rizzo A, Campani V, De Rosa G, Bruna A, Serra V, Mano M, Giacca M, Leonetti C, Ciliberto G, Tarsounas M, Stoppacciaro A, Schoeftner S, Biroccio A. Dinami R, et al. Among authors: porru m. EMBO Mol Med. 2023 Jan 11;15(1):e16033. doi: 10.15252/emmm.202216033. Epub 2022 Nov 25. EMBO Mol Med. 2023. PMID: 36426578 Free PMC article.
TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment.
Zizza P, Dinami R, Porru M, Cingolani C, Salvati E, Rizzo A, D'Angelo C, Petti E, Amoreo CA, Mottolese M, Sperduti I, Chambery A, Russo R, Ostano P, Chiorino G, Blandino G, Sacconi A, Cherfils-Vicini J, Leonetti C, Gilson E, Biroccio A. Zizza P, et al. Among authors: porru m. Nucleic Acids Res. 2019 Apr 23;47(7):3365-3382. doi: 10.1093/nar/gkz041. Nucleic Acids Res. 2019. PMID: 30698737 Free PMC article.
A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.
Salvati E, Rizzo A, Iachettini S, Zizza P, Cingolani C, D'Angelo C, Porru M, Mondello C, Aiello A, Farsetti A, Gilson E, Leonetti C, Biroccio A. Salvati E, et al. Among authors: porru m. Nucleic Acids Res. 2015 Feb 18;43(3):1759-69. doi: 10.1093/nar/gkv006. Epub 2015 Jan 23. Nucleic Acids Res. 2015. PMID: 25618850 Free PMC article.
Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance.
Zizza P, Cingolani C, Artuso S, Salvati E, Rizzo A, D'Angelo C, Porru M, Pagano B, Amato J, Randazzo A, Novellino E, Stoppacciaro A, Gilson E, Stassi G, Leonetti C, Biroccio A. Zizza P, et al. Among authors: porru m. Nucleic Acids Res. 2016 Feb 29;44(4):1579-90. doi: 10.1093/nar/gkv1122. Epub 2015 Oct 27. Nucleic Acids Res. 2016. PMID: 26511095 Free PMC article.
66 results