Poppe L - Search Results

1

Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.

Hu E, Hong FT, Aral J, Long J, Piper DE, Poppe L, Andrews KL, Hager T, Davis C, Li H, Wong P, Gavva N, Shi L, Zhu DXD, Lehto SG, Xu C, Miranda LP. Hu E, et al. Among authors: poppe l. J Med Chem. 2021 Mar 25;64(6):3427-3438. doi: 10.1021/acs.jmedchem.0c01396. Epub 2021 Mar 15. J Med Chem. 2021. PMID: 33715378

2

Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.

Miranda LP, Winters KA, Gegg CV, Patel A, Aral J, Long J, Zhang J, Diamond S, Guido M, Stanislaus S, Ma M, Li H, Rose MJ, Poppe L, Véniant MM. Miranda LP, et al. Among authors: poppe l. J Med Chem. 2008 May 8;51(9):2758-65. doi: 10.1021/jm701522b. Epub 2008 Apr 15. J Med Chem. 2008. PMID: 18412318

3

Hepcidin revisited, disulfide connectivity, dynamics, and structure.

Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier PD, Harvey TS, Miranda LP, Cheetham J, Sasu BJ. Jordan JB, et al. Among authors: poppe l. J Biol Chem. 2009 Sep 4;284(36):24155-67. doi: 10.1074/jbc.M109.017764. Epub 2009 Jun 24. J Biol Chem. 2009. PMID: 19553669 Free PMC article.

4

Fragment based drug discovery: practical implementation based on ¹⁹F NMR spectroscopy.

Jordan JB, Poppe L, Xia X, Cheng AC, Sun Y, Michelsen K, Eastwood H, Schnier PD, Nixey T, Zhong W. Jordan JB, et al. Among authors: poppe l. J Med Chem. 2012 Jan 26;55(2):678-87. doi: 10.1021/jm201441k. Epub 2012 Jan 11. J Med Chem. 2012. PMID: 22165820

5

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.

Murray JK, Ligutti J, Liu D, Zou A, Poppe L, Li H, Andrews KL, Moyer BD, McDonough SI, Favreau P, Stöcklin R, Miranda LP. Murray JK, et al. Among authors: poppe l. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19. J Med Chem. 2015. PMID: 25658507

6

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.

Murray JK, Biswas K, Holder JR, Zou A, Ligutti J, Liu D, Poppe L, Andrews KL, Lin FF, Meng SY, Moyer BD, McDonough SI, Miranda LP. Murray JK, et al. Among authors: poppe l. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4866-4871. doi: 10.1016/j.bmcl.2015.06.033. Epub 2015 Jun 16. Bioorg Med Chem Lett. 2015. PMID: 26112439

7

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.

Murray JK, Long J, Zou A, Ligutti J, Andrews KL, Poppe L, Biswas K, Moyer BD, McDonough SI, Miranda LP. Murray JK, et al. Among authors: poppe l. J Med Chem. 2016 Mar 24;59(6):2704-17. doi: 10.1021/acs.jmedchem.5b01947. Epub 2016 Mar 10. J Med Chem. 2016. PMID: 26890998

8

Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.

Tamayo NA, Bourbeau MP, Allen JR, Ashton KS, Chen JJ, Kaller MR, Nguyen TT, Nishimura N, Pettus LH, Walton M, Belmontes B, Moriguchi J, Chen K, McCarter JD, Hanestad K, Chung G, Ninniri MSS, Sun J, Poppe L, Spahr C, Hui J, Jia L, Wu T, Dahal UP, Edson KZ, Payton M. Tamayo NA, et al. Among authors: poppe l. J Med Chem. 2022 Mar 24;65(6):4972-4990. doi: 10.1021/acs.jmedchem.1c02030. Epub 2022 Mar 14. J Med Chem. 2022. PMID: 35286090

9

PEG: The Magic Bullet for Biophysical Analysis of Highly Aggregating Small Molecules in Aqueous Solutions.

Ingersoll J, Shcherbakov AA, Vaish A, Poppe L. Ingersoll J, et al. Among authors: poppe l. ACS Med Chem Lett. 2023 Jul 31;14(8):1063-1066. doi: 10.1021/acsmedchemlett.3c00198. eCollection 2023 Aug 10. ACS Med Chem Lett. 2023. PMID: 37583825

10

PADLOC: a powerful tool to assign disulfide bond connectivities in peptides and proteins by NMR spectroscopy.

Poppe L, Hui JO, Ligutti J, Murray JK, Schnier PD. Poppe L, et al. Anal Chem. 2012 Jan 3;84(1):262-6. doi: 10.1021/ac203078x. Epub 2011 Dec 19. Anal Chem. 2012. PMID: 22126836

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