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Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.
Sparbier CE, Gillespie A, Gomez J, Kumari N, Motazedian A, Chan KL, Bell CC, Gilan O, Chan YC, Popp S, Gough DJ, Eckersley-Maslin MA, Dawson SJ, Lehner PJ, Sutherland KD, Ernst P, McGeehan GM, Lam EYN, Burr ML, Dawson MA. Sparbier CE, et al. Among authors: popp s. Nat Cell Biol. 2023 Feb;25(2):258-272. doi: 10.1038/s41556-022-01056-x. Epub 2023 Jan 12. Nat Cell Biol. 2023. PMID: 36635503 Free PMC article.
Heparanase and Type 1 Diabetes.
Simeonovic CJ, Popp SK, Brown DJ, Li FJ, Lafferty ARA, Freeman C, Parish CR. Simeonovic CJ, et al. Adv Exp Med Biol. 2020;1221:607-630. doi: 10.1007/978-3-030-34521-1_24. Adv Exp Med Biol. 2020. PMID: 32274728 Review.
Circulating platelet-neutrophil aggregates characterize the development of type 1 diabetes in humans and NOD mice.
Popp SK, Vecchio F, Brown DJ, Fukuda R, Suzuki Y, Takeda Y, Wakamatsu R, Sarma MA, Garrett J, Giovenzana A, Bosi E, Lafferty AR, Brown KJ, Gardiner EE, Coupland LA, Thomas HE, Chong BH, Parish CR, Battaglia M, Petrelli A, Simeonovic CJ. Popp SK, et al. JCI Insight. 2022 Jan 25;7(2):e153993. doi: 10.1172/jci.insight.153993. JCI Insight. 2022. PMID: 35076023 Free PMC article.
136 results