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Page 1
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.
Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW. Pariollaud M, et al. Among authors: poolman t. J Clin Invest. 2018 Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30. J Clin Invest. 2018. PMID: 29533925 Free PMC article.
REVERBa couples the circadian clock to hepatic glucocorticoid action.
Caratti G, Iqbal M, Hunter L, Kim D, Wang P, Vonslow RM, Begley N, Tetley AJ, Woodburn JL, Pariollaud M, Maidstone R, Donaldson IJ, Zhang Z, Ince LM, Kitchen G, Baxter M, Poolman TM, Daniels DA, Stirling DR, Brocker C, Gonzalez F, Loudon AS, Bechtold DA, Rattray M, Matthews LC, Ray DW. Caratti G, et al. J Clin Invest. 2018 Oct 1;128(10):4454-4471. doi: 10.1172/JCI96138. Epub 2018 Sep 4. J Clin Invest. 2018. PMID: 30179226 Free PMC article.
Circadian clock function does not require the histone methyltransferase MLL3.
Baxter M, Poolman T, Cunningham P, Hunter L, Voronkov M, Kitchen GB, Goosey L, Begley N, Kay D, Hespe A, Maidstone R, Loudon ASI, Ray DW. Baxter M, et al. Among authors: poolman t. FASEB J. 2022 Jul;36(7):e22356. doi: 10.1096/fj.202200368R. FASEB J. 2022. PMID: 35704036 Free PMC article.
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Kitchen GB, Cunningham PS, Poolman TM, Iqbal M, Maidstone R, Baxter M, Bagnall J, Begley N, Saer B, Hussell T, Matthews LC, Dockrell DH, Durrington HJ, Gibbs JE, Blaikley JF, Loudon AS, Ray DW. Kitchen GB, et al. Among authors: poolman tm. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1543-1551. doi: 10.1073/pnas.1915932117. Epub 2020 Jan 3. Proc Natl Acad Sci U S A. 2020. PMID: 31900362 Free PMC article.
Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism.
Downton P, Sanna F, Maidstone R, Poolman TM, Hayter EA, Dickson SH, Ciccone NA, Early JO, Adamson A, Spiller DG, Simpkins DA, Baxter M, Fischer R, Rattray M, Loudon ASI, Gibbs JE, Bechtold DA, Ray DW. Downton P, et al. Among authors: poolman tm. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2112781119. doi: 10.1073/pnas.2112781119. Epub 2022 Apr 28. Proc Natl Acad Sci U S A. 2022. PMID: 35482925 Free PMC article.
Nuclear receptor REVERBα is a state-dependent regulator of liver energy metabolism.
Hunter AL, Pelekanou CE, Adamson A, Downton P, Barron NJ, Cornfield T, Poolman TM, Humphreys N, Cunningham PS, Hodson L, Loudon ASI, Iqbal M, Bechtold DA, Ray DW. Hunter AL, et al. Among authors: poolman tm. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25869-25879. doi: 10.1073/pnas.2005330117. Epub 2020 Sep 28. Proc Natl Acad Sci U S A. 2020. PMID: 32989157 Free PMC article.
Rheumatoid arthritis reprograms circadian output pathways.
Poolman TM, Gibbs J, Walker AL, Dickson S, Farrell L, Hensman J, Kendall AC, Maidstone R, Warwood S, Loudon A, Rattray M, Bruce IN, Nicolaou A, Ray DW. Poolman TM, et al. Arthritis Res Ther. 2019 Feb 6;21(1):47. doi: 10.1186/s13075-019-1825-y. Arthritis Res Ther. 2019. PMID: 30728072 Free PMC article.
35 results