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Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations.
Angew Chem Int Ed Engl. 2020 Aug 17;59(34):14481-14489. doi: 10.1002/anie.202003500. Epub 2020 Jul 9.
Angew Chem Int Ed Engl. 2020.
PMID: 32510788
Free PMC article.
Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nowak RP, DeAngelo SL, Buckley D, He Z, Donovan KA, An J, Safaee N, Jedrychowski MP, Ponthier CM, Ishoey M, Zhang T, Mancias JD, Gray NS, Bradner JE, Fischer ES.
Nowak RP, et al. Among authors: ponthier cm.
Nat Chem Biol. 2018 Jul;14(7):706-714. doi: 10.1038/s41589-018-0055-y. Epub 2018 Jun 11.
Nat Chem Biol. 2018.
PMID: 29892083
Free PMC article.
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pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.
An J, Ponthier CM, Sack R, Seebacher J, Stadler MB, Donovan KA, Fischer ES.
An J, et al. Among authors: ponthier cm.
Nat Commun. 2017 May 22;8:15398. doi: 10.1038/ncomms15398.
Nat Commun. 2017.
PMID: 28530236
Free PMC article.
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