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Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag.
Nat Methods. 2023 Jun;20(6):898-907. doi: 10.1038/s41592-023-01859-2. Epub 2023 May 8.
Nat Methods. 2023.
PMID: 37156841
Enhanced Cas12a editing in mammalian cells and zebrafish.
Liu P, Luk K, Shin M, Idrizi F, Kwok S, Roscoe B, Mintzer E, Suresh S, Morrison K, Frazão JB, Bolukbasi MF, Ponnienselvan K, Luban J, Zhu LJ, Lawson ND, Wolfe SA.
Liu P, et al. Among authors: ponnienselvan k.
Nucleic Acids Res. 2019 May 7;47(8):4169-4180. doi: 10.1093/nar/gkz184.
Nucleic Acids Res. 2019.
PMID: 30892626
Free PMC article.
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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice.
Liu P, Liang SQ, Zheng C, Mintzer E, Zhao YG, Ponnienselvan K, Mir A, Sontheimer EJ, Gao G, Flotte TR, Wolfe SA, Xue W.
Liu P, et al. Among authors: ponnienselvan k.
Nat Commun. 2021 Apr 9;12(1):2121. doi: 10.1038/s41467-021-22295-w.
Nat Commun. 2021.
PMID: 33837189
Free PMC article.
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Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency.
Ponnienselvan K, Liu P, Nyalile T, Oikemus S, Maitland SA, Lawson ND, Luban J, Wolfe SA.
Ponnienselvan K, et al.
Nucleic Acids Res. 2023 Jul 21;51(13):6966-6980. doi: 10.1093/nar/gkad456.
Nucleic Acids Res. 2023.
PMID: 37246708
Free PMC article.
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TRIP13 regulates DNA repair pathway choice through REV7 conformational change.
Clairmont CS, Sarangi P, Ponnienselvan K, Galli LD, Csete I, Moreau L, Adelmant G, Chowdhury D, Marto JA, D'Andrea AD.
Clairmont CS, et al. Among authors: ponnienselvan k.
Nat Cell Biol. 2020 Jan;22(1):87-96. doi: 10.1038/s41556-019-0442-y. Epub 2020 Jan 8.
Nat Cell Biol. 2020.
PMID: 31915374
Free PMC article.
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Addressing the dNTP bottleneck restricting prime editing activity.
Ponnienselvan K, Liu P, Nyalile T, Oikemus S, Joynt AT, Kelly K, Guo D, Chen Z, Lee JM, Schiffer CA, Emerson CP, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA.
Ponnienselvan K, et al.
bioRxiv [Preprint]. 2023 Oct 29:2023.10.21.563443. doi: 10.1101/2023.10.21.563443.
bioRxiv. 2023.
PMID: 37904991
Free PMC article.
Preprint.
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Optimization of Nuclear Localization Signal Composition Improves CRISPR-Cas12a Editing Rates in Human Primary Cells.
Luk K, Liu P, Zeng J, Wang Y, Maitland SA, Idrizi F, Ponnienselvan K, Iyer S, Zhu LJ, Luban J, Bauer DE, Wolfe SA.
Luk K, et al. Among authors: ponnienselvan k.
GEN Biotechnol. 2022 Jun;1(3):271-284. doi: 10.1089/genbio.2022.0003. Epub 2022 Jun 14.
GEN Biotechnol. 2022.
PMID: 38405215
Free PMC article.
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USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.
Lim KS, Li H, Roberts EA, Gaudiano EF, Clairmont C, Sambel LA, Ponnienselvan K, Liu JC, Yang C, Kozono D, Parmar K, Yusufzai T, Zheng N, D'Andrea AD.
Lim KS, et al. Among authors: ponnienselvan k.
Mol Cell. 2018 Dec 20;72(6):925-941.e4. doi: 10.1016/j.molcel.2018.10.045.
Mol Cell. 2018.
PMID: 30576655
Free PMC article.
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