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Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.
Metelev M, Osterman IA, Ghilarov D, Khabibullina NF, Yakimov A, Shabalin K, Utkina I, Travin DY, Komarova ES, Serebryakova M, Artamonova T, Khodorkovskii M, Konevega AL, Sergiev PV, Severinov K, Polikanov YS. Metelev M, et al. Among authors: polikanov ys. Nat Chem Biol. 2017 Oct;13(10):1129-1136. doi: 10.1038/nchembio.2462. Epub 2017 Aug 28. Nat Chem Biol. 2017. PMID: 28846667 Free PMC article.
Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Polikanov YS, Osterman IA, Szal T, Tashlitsky VN, Serebryakova MV, Kusochek P, Bulkley D, Malanicheva IA, Efimenko TA, Efremenkova OV, Konevega AL, Shaw KJ, Bogdanov AA, Rodnina MV, Dontsova OA, Mankin AS, Steitz TA, Sergiev PV. Polikanov YS, et al. Mol Cell. 2014 Nov 20;56(4):531-40. doi: 10.1016/j.molcel.2014.09.020. Epub 2014 Oct 9. Mol Cell. 2014. PMID: 25306919 Free PMC article.
Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.
Tereshchenkov AG, Dobosz-Bartoszek M, Osterman IA, Marks J, Sergeeva VA, Kasatsky P, Komarova ES, Stavrianidi AN, Rodin IA, Konevega AL, Sergiev PV, Sumbatyan NV, Mankin AS, Bogdanov AA, Polikanov YS. Tereshchenkov AG, et al. Among authors: polikanov ys. J Mol Biol. 2018 Mar 16;430(6):842-852. doi: 10.1016/j.jmb.2018.01.016. Epub 2018 Feb 2. J Mol Biol. 2018. PMID: 29410130 Free PMC article.
Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides.
Khabibullina NF, Tereshchenkov AG, Komarova ES, Syroegin EA, Shiriaev DI, Paleskava A, Kartsev VG, Bogdanov AA, Konevega AL, Dontsova OA, Sergiev PV, Osterman IA, Polikanov YS. Khabibullina NF, et al. Among authors: polikanov ys. Antimicrob Agents Chemother. 2019 May 24;63(6):e02266-18. doi: 10.1128/AAC.02266-18. Print 2019 Jun. Antimicrob Agents Chemother. 2019. PMID: 30936109 Free PMC article.
63 results