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Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion.
Pallavi R, Gatti E, Durfort T, Stendardo M, Ravasio R, Leonardi T, Falvo P, Duso BA, Punzi S, Xieraili A, Polazzi A, Verrelli D, Trastulli D, Ronzoni S, Frascolla S, Perticari G, Elgendy M, Varasi M, Colombo E, Giorgio M, Lanfrancone L, Minucci S, Mazzarella L, Pelicci PG. Pallavi R, et al. Among authors: polazzi a. Nat Commun. 2024 Jan 27;15(1):828. doi: 10.1038/s41467-023-44348-y. Nat Commun. 2024. PMID: 38280853 Free PMC article.
A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer.
Roda N, Cossa A, Hillje R, Tirelli A, Ruscitto F, Cheloni S, Priami C, Dalmasso A, Gambino V, Blandano G, Polazzi A, Falvo P, Gatti E, Mazzarella L, Luzi L, Migliaccio E, Pelicci PG. Roda N, et al. Among authors: polazzi a. Cancer Res. 2023 Jul 5;83(13):2155-2170. doi: 10.1158/0008-5472.CAN-22-2717. Cancer Res. 2023. PMID: 37133448
Aberrant activation of p53/p66Shc-mInsc axis increases asymmetric divisions and attenuates proliferation of aged mammary stem cells.
Priami C, Montariello D, De Michele G, Ruscitto F, Polazzi A, Ronzoni S, Bertalot G, Binelli G, Gambino V, Luzi L, Mapelli M, Giorgio M, Migliaccio E, Pelicci PG. Priami C, et al. Among authors: polazzi a. Cell Death Differ. 2022 Dec;29(12):2429-2444. doi: 10.1038/s41418-022-01029-5. Epub 2022 Jun 23. Cell Death Differ. 2022. PMID: 35739253 Free PMC article.