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PARP1 associates with R-loops to promote their resolution and genome stability.
Laspata N, Kaur P, Mersaoui SY, Muoio D, Liu ZS, Bannister MH, Nguyen HD, Curry C, Pascal JM, Poirier GG, Wang H, Masson JY, Fouquerel E. Laspata N, et al. Among authors: poirier gg. Nucleic Acids Res. 2023 Mar 21;51(5):2215-2237. doi: 10.1093/nar/gkad066. Nucleic Acids Res. 2023. PMID: 36794853 Free PMC article.
ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance.
O'Sullivan J, Kothari C, Caron MC, Gagné JP, Jin Z, Nonfoux L, Beneyton A, Coulombe Y, Thomas M, Atalay N, Meng XW, Milano L, Jean D, Boisvert FM, Kaufmann SH, Hendzel MJ, Masson JY, Poirier GG. O'Sullivan J, et al. Among authors: poirier gg. Nucleic Acids Res. 2023 Nov 10;51(20):11056-11079. doi: 10.1093/nar/gkad791. Nucleic Acids Res. 2023. PMID: 37823600 Free PMC article.
Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation.
Mubaid S, Sanchez BJ, Algehani RA, Skopenkova V, Adjibade P, Hall DT, Busque S, Lian XJ, Ashour K, Tremblay AK, Carlile G, Gagné JP, Diaz-Gaxiola A, Khattak S, Di Marco S, Thomas DY, Poirier GG, Gallouzi IE. Mubaid S, et al. Among authors: poirier gg. Nucleic Acids Res. 2024 Apr 24;52(7):4002-4020. doi: 10.1093/nar/gkae059. Nucleic Acids Res. 2024. PMID: 38321934 Free PMC article.
Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus.
Becker YLC, Gagné JP, Julien AS, Lévesque T, Allaeys I, Gougeard N, Rubio V, Boisvert FM, Jean D, Wagner E, Poirier GG, Fortin PR, Boilard É. Becker YLC, et al. Among authors: poirier gg. Arthritis Rheumatol. 2022 Jul;74(7):1193-1203. doi: 10.1002/art.42082. Epub 2022 Jun 6. Arthritis Rheumatol. 2022. PMID: 35128841
ADP-ribosyltransferases, an update on function and nomenclature.
Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M. Lüscher B, et al. Among authors: poirier gg. FEBS J. 2022 Dec;289(23):7399-7410. doi: 10.1111/febs.16142. Epub 2021 Sep 13. FEBS J. 2022. PMID: 34323016 Free PMC article.
PARP-1 activation leads to cytosolic accumulation of TDP-43 in neurons.
Marcus JM, Hossain MI, Gagné JP, Poirier GG, McMahon LL, Cowell RM, Andrabi SA. Marcus JM, et al. Among authors: poirier gg. Neurochem Int. 2021 Sep;148:105077. doi: 10.1016/j.neuint.2021.105077. Epub 2021 May 31. Neurochem Int. 2021. PMID: 34082062
283 results