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Page 1
Genetic risk converges on regulatory networks mediating early type 2 diabetes.
Walker JT, Saunders DC, Rai V, Chen HH, Orchard P, Dai C, Pettway YD, Hopkirk AL, Reihsmann CV, Tao Y, Fan S, Shrestha S, Varshney A, Petty LE, Wright JJ, Ventresca C, Agarwala S, Aramandla R, Poffenberger G, Jenkins R, Mei S, Hart NJ, Phillips S, Kang H, Greiner DL, Shultz LD, Bottino R, Liu J, Below JE; HPAP Consortium; Parker SCJ, Powers AC, Brissova M. Walker JT, et al. Among authors: poffenberger g. Nature. 2023 Dec;624(7992):621-629. doi: 10.1038/s41586-023-06693-2. Epub 2023 Dec 4. Nature. 2023. PMID: 38049589
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC. Brissova M, et al. Among authors: poffenberger g. Cell Rep. 2018 Mar 6;22(10):2667-2676. doi: 10.1016/j.celrep.2018.02.032. Cell Rep. 2018. PMID: 29514095 Free PMC article.
Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks.
Haliyur R, Tong X, Sanyoura M, Shrestha S, Lindner J, Saunders DC, Aramandla R, Poffenberger G, Redick SD, Bottino R, Prasad N, Levy SE, Blind RD, Harlan DM, Philipson LH, Stein RW, Brissova M, Powers AC. Haliyur R, et al. Among authors: poffenberger g. J Clin Invest. 2019 Jan 2;129(1):246-251. doi: 10.1172/JCI121994. Epub 2018 Dec 3. J Clin Invest. 2019. PMID: 30507613 Free PMC article.
Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells.
Walker JT, Haliyur R, Nelson HA, Ishahak M, Poffenberger G, Aramandla R, Reihsmann C, Luchsinger JR, Saunders DC, Wang P, Garcia-Ocaña A, Bottino R, Agarwal A, Powers AC, Brissova M. Walker JT, et al. Among authors: poffenberger g. JCI Insight. 2020 May 21;5(10):e137017. doi: 10.1172/jci.insight.137017. JCI Insight. 2020. PMID: 32352931 Free PMC article.
Decreased pancreatic acinar cell number in type 1 diabetes.
Wright JJ, Saunders DC, Dai C, Poffenberger G, Cairns B, Serreze DV, Harlan DM, Bottino R, Brissova M, Powers AC. Wright JJ, et al. Among authors: poffenberger g. Diabetologia. 2020 Jul;63(7):1418-1423. doi: 10.1007/s00125-020-05155-y. Epub 2020 May 9. Diabetologia. 2020. PMID: 32388592 Free PMC article.
Combinatorial transcription factor profiles predict mature and functional human islet α and β cells.
Shrestha S, Saunders DC, Walker JT, Camunas-Soler J, Dai XQ, Haliyur R, Aramandla R, Poffenberger G, Prasad N, Bottino R, Stein R, Cartailler JP, Parker SC, MacDonald PE, Levy SE, Powers AC, Brissova M. Shrestha S, et al. Among authors: poffenberger g. JCI Insight. 2021 Sep 22;6(18):e151621. doi: 10.1172/jci.insight.151621. JCI Insight. 2021. PMID: 34428183 Free PMC article.
Integrated Analysis of the Pancreas and Islets Reveals Unexpected Findings in Human Male With Type 1 Diabetes.
Haliyur R, Walker JT, Sanyoura M, Reihsmann CV, Shrestha S, Aramandla R, Poffenberger G, Ramirez AH, Redick SD, Babon JAB, Prasad N, Hegele RA, Kent SC, Harlan DM, Bottino R, Philipson LH, Brissova M, Powers AC. Haliyur R, et al. Among authors: poffenberger g. J Endocr Soc. 2021 Oct 29;5(12):bvab162. doi: 10.1210/jendso/bvab162. eCollection 2021 Dec 1. J Endocr Soc. 2021. PMID: 34870058 Free PMC article.
Dapagliflozin Does Not Directly Affect Human α or β Cells.
Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC. Dai C, et al. Among authors: poffenberger g. Endocrinology. 2020 Aug 1;161(8):bqaa080. doi: 10.1210/endocr/bqaa080. Endocrinology. 2020. PMID: 32428240 Free PMC article.
42 results