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Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-ij]Quinolin-2(1H)-one as New Inhibitors of Factor Xa and Factor XIa.
Novichikhina N, Ilin I, Tashchilova A, Sulimov A, Kutov D, Ledenyova I, Krysin M, Shikhaliev K, Gantseva A, Gantseva E, Podoplelova N, Sulimov V. Novichikhina N, et al. Among authors: podoplelova n. Molecules. 2020 Apr 19;25(8):1889. doi: 10.3390/molecules25081889. Molecules. 2020. PMID: 32325823 Free PMC article.
New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation.
Novichikhina NP, Shestakov AS, Medvedeva SM, Lagutina AM, Krysin MY, Podoplelova NA, Panteleev MA, Ilin IS, Sulimov AV, Tashchilova AS, Sulimov VB, Geronikaki A, Shikhaliev KS. Novichikhina NP, et al. Among authors: podoplelova na. Molecules. 2023 May 1;28(9):3851. doi: 10.3390/molecules28093851. Molecules. 2023. PMID: 37175261 Free PMC article.
Hysteresis-like binding of coagulation factors X/Xa to procoagulant activated platelets and phospholipids results from multistep association and membrane-dependent multimerization.
Podoplelova NA, Sveshnikova AN, Kurasawa JH, Sarafanov AG, Chambost H, Vasil'ev SA, Demina IA, Ataullakhanov FI, Alessi MC, Panteleev MA. Podoplelova NA, et al. Biochim Biophys Acta. 2016 Jun;1858(6):1216-27. doi: 10.1016/j.bbamem.2016.02.008. Epub 2016 Feb 10. Biochim Biophys Acta. 2016. PMID: 26874201 Free article. Review.
Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates.
Abaeva AA, Canault M, Kotova YN, Obydennyy SI, Yakimenko AO, Podoplelova NA, Kolyadko VN, Chambost H, Mazurov AV, Ataullakhanov FI, Nurden AT, Alessi MC, Panteleev MA. Abaeva AA, et al. Among authors: podoplelova na. J Biol Chem. 2013 Oct 11;288(41):29621-32. doi: 10.1074/jbc.M113.474163. Epub 2013 Aug 30. J Biol Chem. 2013. PMID: 23995838 Free PMC article.
21 results