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Novel CDK12/13 Inhibitors AU-15506 and AU-16770 Are Potent Anti-Cancer Agents in EGFR Mutant Lung Adenocarcinoma with and without Osimertinib Resistance.
Maity TK, Kim EY, Cultraro CM, Venugopalan A, Khare L, Poddutoori R, Marappan S, Syed SD, Telford WG, Samajdar S, Ramachandra M, Guha U. Maity TK, et al. Among authors: poddutoori r. Cancers (Basel). 2023 Apr 12;15(8):2263. doi: 10.3390/cancers15082263. Cancers (Basel). 2023. PMID: 37190191 Free PMC article.
Novel covalent CDK7 inhibitor potently induces apoptosis in acute myeloid leukemia and synergizes with Venetoclax.
Gaur T, Poddutoori R, Khare L, Bagal B, Rashmi S, Patkar N, Tembhare P, Pg S, Shetty D, Dutt A, Zhang Q, Konopleva M, Platzbeckar U, Gupta S, Samajdar S, Ramchandra M, Khattry N, Hasan SK. Gaur T, et al. Among authors: poddutoori r. J Exp Clin Cancer Res. 2023 Jul 29;42(1):186. doi: 10.1186/s13046-023-02750-w. J Exp Clin Cancer Res. 2023. PMID: 37507802 Free PMC article.
A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation.
Nakamura Y, Urakami T, Ishimaru K, Vuong Tran NQ, Shimizu T, Sinko W, Takahashi T, Marappan S, Narayanan K, Poddutoori R, Terada Y, Nakao A. Nakamura Y, et al. Among authors: poddutoori r. J Allergy Clin Immunol Glob. 2024 Apr 3;3(3):100249. doi: 10.1016/j.jacig.2024.100249. eCollection 2024 Aug. J Allergy Clin Immunol Glob. 2024. PMID: 38764489 Free PMC article.
Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
Poddutoori R, Aardalen K, Aithal K, Barahagar SS, Belliappa C, Bock M, Chelur S, Gerken A, Gopinath S, Gruenenfelder B, Kiffe M, Krishnaswami M, Langowski J, Madapa S, Narayanan K, Pandit C, Panigrahi SK, Perrone M, Potakamuri RK, Ramachandra M, Ramanathan A, Ramos R, Sager E, Samajdar S, Subramanya HS, Thimmasandra DS, Venetsanakos E, Möbitz H. Poddutoori R, et al. J Med Chem. 2022 Mar 10;65(5):4350-4366. doi: 10.1021/acs.jmedchem.1c02192. Epub 2022 Feb 23. J Med Chem. 2022. PMID: 35195996
Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.
Guerrero M, Poddutoori R, Urbano M, Peng X, Spicer TP, Chase PS, Hodder PS, Schaeffer MT, Brown S, Rosen H, Roberts E. Guerrero M, et al. Among authors: poddutoori r. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6346-9. doi: 10.1016/j.bmcl.2013.09.075. Epub 2013 Oct 1. Bioorg Med Chem Lett. 2013. PMID: 24135724 Free PMC article.
Probe Development Efforts for an Allosteric Agonist of the Sphingosine 1-phosphate Receptor 3 (S1P3).
Guerrero M, Poddutoori R, Pinacho-Crisostomo F, Schaeffer MT, Brown SJ, Spicer T, Chase P, Ferguson J, Roberts E, Sanna G, Hodder P, Rosen H. Guerrero M, et al. Among authors: poddutoori r. 2011 Aug 31 [updated 2013 Feb 25]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2011 Aug 31 [updated 2013 Feb 25]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23658964 Free Books & Documents. Review.