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Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain.
Szczepańska K, Karcz T, Dichiara M, Mogilski S, Kalinowska-Tłuścik J, Pilarski B, Leniak A, Pietruś W, Podlewska S, Popiołek-Barczyk K, Humphrys LJ, Ruiz-Cantero MC, Reiner-Link D, Leitzbach L, Łażewska D, Pockes S, Górka M, Zmysłowski A, Calmels T, Cobos EJ, Marrazzo A, Stark H, Bojarski AJ, Amata E, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: pockes s. J Med Chem. 2023 Jul 27;66(14):9658-9683. doi: 10.1021/acs.jmedchem.3c00430. Epub 2023 Jul 7. J Med Chem. 2023. PMID: 37418295 Free PMC article.
Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent.
Szczepańska K, Pockes S, Podlewska S, Höring C, Mika K, Latacz G, Bednarski M, Siwek A, Karcz T, Nagl M, Bresinsky M, Mönnich D, Seibel U, Kuder KJ, Kotańska M, Stark H, Elz S, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: pockes s. Eur J Med Chem. 2021 Mar 5;213:113041. doi: 10.1016/j.ejmech.2020.113041. Epub 2020 Nov 24. Eur J Med Chem. 2021. PMID: 33261900
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties.
Szczepańska K, Podlewska S, Dichiara M, Gentile D, Patamia V, Rosier N, Mönnich D, Ruiz Cantero MC, Karcz T, Łażewska D, Siwek A, Pockes S, Cobos EJ, Marrazzo A, Stark H, Rescifina A, Bojarski AJ, Amata E, Kieć-Kononowicz K. Szczepańska K, et al. Among authors: pockes s. ACS Chem Neurosci. 2022 Jan 5;13(1):1-15. doi: 10.1021/acschemneuro.1c00435. Epub 2021 Dec 15. ACS Chem Neurosci. 2022. PMID: 34908391 Free PMC article.
Ergometrine stimulates histamine H2 receptors in the isolated human atrium.
Jacob H, Braekow P, Hofmann B, Kirchhefer U, Forster L, Mönnich D, Humphrys LJ, Pockes S, Neumann J, Gergs U. Jacob H, et al. Among authors: pockes s. Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec;396(12):3809-3822. doi: 10.1007/s00210-023-02573-8. Epub 2023 Jun 24. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37354215 Free PMC article.
Clonidine stimulates force of contraction via histamine H2 receptors in the human atrium.
Neumann J, Pockes S, Humphrys LJ, Mönnich D, Forster L, Kirchhefer U, Hofmann B, Gergs U. Neumann J, et al. Among authors: pockes s. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jan;397(1):617-626. doi: 10.1007/s00210-023-02635-x. Epub 2023 Jul 25. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37490122 Free PMC article.
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