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Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation.
Laghezza A, Piemontese L, Cerchia C, Montanari R, Capelli D, Giudici M, Crestani M, Tortorella P, Peiretti F, Pochetti G, Lavecchia A, Loiodice F. Laghezza A, et al. Among authors: pochetti g. J Med Chem. 2018 Sep 27;61(18):8282-8298. doi: 10.1021/acs.jmedchem.8b00835. Epub 2018 Sep 18. J Med Chem. 2018. PMID: 30199253
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand-macromolecule interaction.
Calleri E, Fracchiolla G, Montanari R, Pochetti G, Lavecchia A, Loiodice F, Laghezza A, Piemontese L, Massolini G, Temporini C. Calleri E, et al. Among authors: pochetti g. J Chromatogr A. 2012 Apr 6;1232:84-92. doi: 10.1016/j.chroma.2011.10.037. Epub 2011 Oct 19. J Chromatogr A. 2012. PMID: 22056242
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.
Laghezza A, Pochetti G, Lavecchia A, Fracchiolla G, Faliti S, Piemontese L, Di Giovanni C, Iacobazzi V, Infantino V, Montanari R, Capelli D, Tortorella P, Loiodice F. Laghezza A, et al. Among authors: pochetti g. J Med Chem. 2013 Jan 10;56(1):60-72. doi: 10.1021/jm301018z. Epub 2012 Dec 18. J Med Chem. 2013. PMID: 23171045
Resveratrol and its metabolites bind to PPARs.
Calleri E, Pochetti G, Dossou KSS, Laghezza A, Montanari R, Capelli D, Prada E, Loiodice F, Massolini G, Bernier M, Moaddel R. Calleri E, et al. Among authors: pochetti g. Chembiochem. 2014 May 26;15(8):1154-1160. doi: 10.1002/cbic.201300754. Epub 2014 May 5. Chembiochem. 2014. PMID: 24796862 Free PMC article.
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
Pochetti G, Godio C, Mitro N, Caruso D, Galmozzi A, Scurati S, Loiodice F, Fracchiolla G, Tortorella P, Laghezza A, Lavecchia A, Novellino E, Mazza F, Crestani M. Pochetti G, et al. J Biol Chem. 2007 Jun 8;282(23):17314-24. doi: 10.1074/jbc.M702316200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403688 Free article.
Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.
Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Montanari R, et al. Among authors: pochetti g. J Med Chem. 2008 Dec 25;51(24):7768-76. doi: 10.1021/jm800733h. J Med Chem. 2008. PMID: 19053776
55 results