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Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity.
Tauro M, Laghezza A, Loiodice F, Piemontese L, Caradonna A, Capelli D, Montanari R, Pochetti G, Di Pizio A, Agamennone M, Campestre C, Tortorella P. Tauro M, et al. Among authors: pochetti g. J Enzyme Inhib Med Chem. 2016;31(sup4):25-37. doi: 10.1080/14756366.2016.1217853. Epub 2016 Aug 24. J Enzyme Inhib Med Chem. 2016. PMID: 27556138
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation.
Laghezza A, Piemontese L, Cerchia C, Montanari R, Capelli D, Giudici M, Crestani M, Tortorella P, Peiretti F, Pochetti G, Lavecchia A, Loiodice F. Laghezza A, et al. Among authors: pochetti g. J Med Chem. 2018 Sep 27;61(18):8282-8298. doi: 10.1021/acs.jmedchem.8b00835. Epub 2018 Sep 18. J Med Chem. 2018. PMID: 30199253
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Porcelli L, Gilardi F, Laghezza A, Piemontese L, Mitro N, Azzariti A, Altieri F, Cervoni L, Fracchiolla G, Giudici M, Guerrini U, Lavecchia A, Montanari R, Di Giovanni C, Paradiso A, Pochetti G, Simone GM, Tortorella P, Crestani M, Loiodice F. Porcelli L, et al. Among authors: pochetti g. J Med Chem. 2012 Jan 12;55(1):37-54. doi: 10.1021/jm201306q. Epub 2011 Dec 2. J Med Chem. 2012. PMID: 22081932
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.
Laghezza A, Pochetti G, Lavecchia A, Fracchiolla G, Faliti S, Piemontese L, Di Giovanni C, Iacobazzi V, Infantino V, Montanari R, Capelli D, Tortorella P, Loiodice F. Laghezza A, et al. Among authors: pochetti g. J Med Chem. 2013 Jan 10;56(1):60-72. doi: 10.1021/jm301018z. Epub 2012 Dec 18. J Med Chem. 2013. PMID: 23171045
Resveratrol and its metabolites bind to PPARs.
Calleri E, Pochetti G, Dossou KSS, Laghezza A, Montanari R, Capelli D, Prada E, Loiodice F, Massolini G, Bernier M, Moaddel R. Calleri E, et al. Among authors: pochetti g. Chembiochem. 2014 May 26;15(8):1154-1160. doi: 10.1002/cbic.201300754. Epub 2014 May 5. Chembiochem. 2014. PMID: 24796862 Free PMC article.
Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.
Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Montanari R, et al. Among authors: pochetti g. J Med Chem. 2008 Dec 25;51(24):7768-76. doi: 10.1021/jm800733h. J Med Chem. 2008. PMID: 19053776
55 results