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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.
Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD. Plovier H, et al. Nat Med. 2017 Jan;23(1):107-113. doi: 10.1038/nm.4236. Epub 2016 Nov 28. Nat Med. 2017. PMID: 27892954 Free article. Clinical Trial.
Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status.
Everard A, Geurts L, Caesar R, Van Hul M, Matamoros S, Duparc T, Denis RG, Cochez P, Pierard F, Castel J, Bindels LB, Plovier H, Robine S, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD. Everard A, et al. Among authors: plovier h. Nat Commun. 2014 Dec 5;5:5648. doi: 10.1038/ncomms6648. Nat Commun. 2014. PMID: 25476696 Free PMC article.
Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis.
Everard A, Plovier H, Rastelli M, Van Hul M, de Wouters d'Oplinter A, Geurts L, Druart C, Robine S, Delzenne NM, Muccioli GG, de Vos WM, Luquet S, Flamand N, Di Marzo V, Cani PD. Everard A, et al. Among authors: plovier h. Nat Commun. 2019 Jan 28;10(1):457. doi: 10.1038/s41467-018-08051-7. Nat Commun. 2019. PMID: 30692526 Free PMC article.
Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.
Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S, Falony G, Raes J, Maiter D, Delzenne NM, de Barsy M, Loumaye A, Hermans MP, Thissen JP, de Vos WM, Cani PD. Depommier C, et al. Among authors: plovier h. Nat Med. 2019 Jul;25(7):1096-1103. doi: 10.1038/s41591-019-0495-2. Epub 2019 Jul 1. Nat Med. 2019. PMID: 31263284 Free PMC article. Clinical Trial.
Toxicological safety evaluation of pasteurized Akkermansia muciniphila.
Druart C, Plovier H, Van Hul M, Brient A, Phipps KR, de Vos WM, Cani PD. Druart C, et al. Among authors: plovier h. J Appl Toxicol. 2021 Feb;41(2):276-290. doi: 10.1002/jat.4044. Epub 2020 Jul 28. J Appl Toxicol. 2021. PMID: 32725676 Free PMC article.
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