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LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
Belluzzi E, Gonnelli A, Cirnaru MD, Marte A, Plotegher N, Russo I, Civiero L, Cogo S, Carrion MP, Franchin C, Arrigoni G, Beltramini M, Bubacco L, Onofri F, Piccoli G, Greggio E. Belluzzi E, et al. Among authors: plotegher n. Mol Neurodegener. 2016 Jan 13;11:1. doi: 10.1186/s13024-015-0066-z. Mol Neurodegener. 2016. PMID: 26758690 Free PMC article.
LRRK2 deficiency impacts ceramide metabolism in brain.
Ferrazza R, Cogo S, Melrose H, Bubacco L, Greggio E, Guella G, Civiero L, Plotegher N. Ferrazza R, et al. Among authors: plotegher n. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1141-6. doi: 10.1016/j.bbrc.2016.08.082. Epub 2016 Aug 15. Biochem Biophys Res Commun. 2016. PMID: 27539321
Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance.
Streubel-Gallasch L, Giusti V, Sandre M, Tessari I, Plotegher N, Giusto E, Masato A, Iovino L, Battisti I, Arrigoni G, Shimshek D, Greggio E, Tremblay ME, Bubacco L, Erlandsson A, Civiero L. Streubel-Gallasch L, et al. Among authors: plotegher n. Mol Neurobiol. 2021 Jul;58(7):3119-3140. doi: 10.1007/s12035-021-02327-8. Epub 2021 Feb 24. Mol Neurobiol. 2021. PMID: 33629273 Free PMC article.
38 results