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Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut.
Lynch JP, González-Prieto C, Reeves AZ, Bae S, Powale U, Godbole NP, Tremblay JM, Schmidt FI, Ploegh HL, Kansra V, Glickman JN, Leong JM, Shoemaker CB, Garrett WS, Lesser CF. Lynch JP, et al. Among authors: ploegh hl. Cell Host Microbe. 2023 Apr 12;31(4):634-649.e8. doi: 10.1016/j.chom.2023.03.007. Epub 2023 Mar 31. Cell Host Microbe. 2023. PMID: 37003258 Free PMC article.
Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS. Huang YH, et al. Among authors: ploegh hl. Nature. 2024 Feb;626(8001):E19. doi: 10.1038/s41586-024-07164-y. Nature. 2024. PMID: 38336833 No abstract available.
MICA-specific nanobodies for diagnosis and immunotherapy of MICA+ tumors.
Verhaar ER, Knoflook A, Pishesha N, Liu X, van Keizerswaard WJC, Wucherpfennig KW, Ploegh HL. Verhaar ER, et al. Among authors: ploegh hl. Front Immunol. 2024 Mar 14;15:1368586. doi: 10.3389/fimmu.2024.1368586. eCollection 2024. Front Immunol. 2024. PMID: 38550583 Free PMC article.
USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism.
Gan J, Pinto-Fernández A, Flierman D, Akkermans JJLL, O'Brien DP, Greenwood H, Scott HC, Fritz G, Knobeloch KP, Neefjes J, van Dam H, Ovaa H, Ploegh HL, Kessler BM, Geurink PP, Sapmaz A. Gan J, et al. Among authors: ploegh hl. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2315163120. doi: 10.1073/pnas.2315163120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055744
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages.
Bates TA, Trank-Greene M, Nguyenla X, Anastas A, Gurmessa SK, Merutka IR, Dixon SD, Shumate A, Groncki AR, Parson MA, Ingram JR, Barklis E, Burke JE, Shinde U, Ploegh HL, Tafesse FG. Bates TA, et al. Among authors: ploegh hl. bioRxiv [Preprint]. 2024 Mar 19:2023.08.16.553641. doi: 10.1101/2023.08.16.553641. bioRxiv. 2024. PMID: 37645775 Free PMC article. Preprint.
Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells.
Engelen SE, Ververs FA, Markovska A, Lagerholm BC, Kraaijenhof JM, Yousif LI, Zurke YX, Gulersonmez CM, Kooijman S, Goddard M, van Eijkeren RJ, Jervis PJ, Besra GS, Haitjema S, Asselbergs FW, Kalkhoven E, Ploegh HL, Boes M, Cerundolo V, Hovingh GK, Salio M, Stigter EC, Rensen PC, Monaco C, Schipper HS. Engelen SE, et al. Among authors: ploegh hl. JCI Insight. 2023 May 8;8(9):e158089. doi: 10.1172/jci.insight.158089. JCI Insight. 2023. PMID: 36976644 Free PMC article.
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.
Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI. Jenster LM, et al. Among authors: ploegh hl. J Exp Med. 2023 Jan 2;220(1):e20220837. doi: 10.1084/jem.20220837. Epub 2022 Oct 31. J Exp Med. 2023. PMID: 36315050 Free PMC article.
525 results