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Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass.
Maupin KA, Himes ER, Plett AP, Chua HL, Singh P, Ghosh J, Mohamad SF, Abeysekera I, Fisher A, Sampson C, Hong JM, Childress P, Alvarez M, Srour EF, Bruzzaniti A, Pelus LM, Orschell CM, Kacena MA. Maupin KA, et al. Among authors: plett ap. Bone. 2019 Oct;127:452-459. doi: 10.1016/j.bone.2019.07.010. Epub 2019 Jul 9. Bone. 2019. PMID: 31299382 Free PMC article.
Pyk2 regulates megakaryocyte-induced increases in osteoblast number and bone formation.
Cheng YH, Hooker RA, Nguyen K, Gerard-O'Riley R, Waning DL, Chitteti BR, Meijome TE, Chua HL, Plett AP, Orschell CM, Srour EF, Mayo LD, Pavalko FM, Bruzzaniti A, Kacena MA. Cheng YH, et al. Among authors: plett ap. J Bone Miner Res. 2013 Jun;28(6):1434-45. doi: 10.1002/jbmr.1876. J Bone Miner Res. 2013. PMID: 23362087 Free PMC article.