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Saponin-Rich Extracts and Their Acid Hydrolysates Differentially Target Colorectal Cancer Metabolism in the Frame of Precision Nutrition.
Cancers (Basel). 2020 Nov 17;12(11):3399. doi: 10.3390/cancers12113399.
Cancers (Basel). 2020.
PMID: 33212825
Free PMC article.
The purpose of this study was to assess and compare the inhibitory effects on colorectal cancer cell lines of saponin-rich extracts from fenugreek and quinoa (FE and QE, respectively) and their hydrolyzed extracts as sapogenin-rich extracts (HFE and HQE, respectively). ... …
The purpose of this study was to assess and compare the inhibitory effects on colorectal cancer cell lines of saponin-rich extracts f …
Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.
Cuyàs E, Verdura S, Llorach-Pares L, Fernández-Arroyo S, Luciano-Mateo F, Cabré N, Stursa J, Werner L, Martin-Castillo B, Viollet B, Neuzil J, Joven J, Nonell-Canals A, Sanchez-Martinez M, Menendez JA.
Cuyàs E, et al.
Aging Cell. 2018 Aug;17(4):e12772. doi: 10.1111/acel.12772. Epub 2018 May 8.
Aging Cell. 2018.
PMID: 29740925
Free PMC article.
Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of aging per se, has been clinically exploited for decades in the absence of a complete understanding of its therapeutic targets or chemical determinants. ...
Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of aging per se, has been clinically ex …
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