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Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia.
Nat Commun. 2022 Mar 30;13(1):1673. doi: 10.1038/s41467-022-29039-4.
Nat Commun. 2022.
PMID: 35354808
Free PMC article.
Clinical Trial.
Adenosine Monophosphate Activated Protein Kinase (AMPK) enhances chemotherapy response in Acute Myeloid Leukemia (AML).
Ghiraldeli L, Anderson R, Pladna K, Pardee TS.
Ghiraldeli L, et al.
Cancer Lett. 2022 Jun 1;535:215659. doi: 10.1016/j.canlet.2022.215659. Epub 2022 Mar 20.
Cancer Lett. 2022.
PMID: 35321842
Free PMC article.
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A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia.
Pardee TS, Anderson RG, Pladna KM, Isom S, Ghiraldeli LP, Miller LD, Chou JW, Jin G, Zhang W, Ellis LR, Berenzon D, Howard DS, Hurd DD, Manuel M, Dralle S, Lyerly S, Powell BL.
Pardee TS, et al. Among authors: pladna km.
Clin Cancer Res. 2018 May 1;24(9):2060-2073. doi: 10.1158/1078-0432.CCR-17-2282. Epub 2018 Feb 6.
Clin Cancer Res. 2018.
PMID: 29437791
Free PMC article.
Clinical Trial.
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The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia.
Alexander PM, Caudell DL, Kucera GL, Pladna KM, Pardee TS.
Alexander PM, et al. Among authors: pladna km.
PLoS One. 2017 Jun 23;12(6):e0179798. doi: 10.1371/journal.pone.0179798. eCollection 2017.
PLoS One. 2017.
PMID: 28644853
Free PMC article.
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The Novel Phospholipid Mimetic KPC34 Is Highly Active Against Acute Myeloid Leukemia with Activated Protein Kinase C.
Alexander PM, Kucera GL, Pladna KM, Pardee TS.
Alexander PM, et al. Among authors: pladna km.
Transl Oncol. 2020 Jul;13(7):100780. doi: 10.1016/j.tranon.2020.100780. Epub 2020 May 16.
Transl Oncol. 2020.
PMID: 32428837
Free PMC article.
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Pyruvate Dehydrogenase Inhibition Leads to Decreased Glycolysis, Increased Reliance on Gluconeogenesis and Alternative Sources of Acetyl-CoA in Acute Myeloid Leukemia.
Anderson R, Pladna KM, Schramm NJ, Wheeler FB, Kridel S, Pardee TS.
Anderson R, et al. Among authors: pladna km.
Cancers (Basel). 2023 Jan 12;15(2):484. doi: 10.3390/cancers15020484.
Cancers (Basel). 2023.
PMID: 36672433
Free PMC article.
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