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Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.
Sandusky-Beltran LA, Kovalenko A, Ma C, Calahatian JIT, Placides DS, Watler MD, Hunt JB, Darling AL, Baker JD, Blair LJ, Martin MD, Fontaine SN, Dickey CA, Lussier AL, Weeber EJ, Selenica MB, Nash KR, Gordon MN, Morgan D, Lee DC. Sandusky-Beltran LA, et al. Among authors: placides ds. Alzheimers Res Ther. 2019 Jun 29;11(1):58. doi: 10.1186/s13195-019-0507-y. Alzheimers Res Ther. 2019. PMID: 31253191 Free PMC article.
Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.
Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB Jr, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, Gamsby JJ, Nash KR, Abner E, Selenica MB, Lee DC. Sandusky-Beltran LA, et al. Among authors: placides ds. J Clin Invest. 2021 Feb 15;131(4):e126299. doi: 10.1172/JCI126299. J Clin Invest. 2021. PMID: 33586680 Free PMC article.
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
Hunt JB Jr, Nash KR, Placides D, Moran P, Selenica ML, Abuqalbeen F, Ratnasamy K, Slouha N, Rodriguez-Ospina S, Savlia M, Ranaweera Y, Reid P, Dickey CA, Uricia R, Yang CG, Sandusky LA, Gordon MN, Morgan D, Lee DC. Hunt JB Jr, et al. J Neurosci. 2015 Nov 4;35(44):14842-60. doi: 10.1523/JNEUROSCI.3959-14.2015. J Neurosci. 2015. PMID: 26538654 Free PMC article.
Arginase 1 Insufficiency Precipitates Amyloid-β Deposition and Hastens Behavioral Impairment in a Mouse Model of Amyloidosis.
Ma C, Hunt JB, Selenica MB, Sanneh A, Sandusky-Beltran LA, Watler M, Daas R, Kovalenko A, Liang H, Placides D, Cao C, Lin X, Orr MB, Zhang B, Gensel JC, Feola DJ, Gordon MN, Morgan D, Bickford PC, Lee DC. Ma C, et al. Front Immunol. 2021 Jan 14;11:582998. doi: 10.3389/fimmu.2020.582998. eCollection 2020. Front Immunol. 2021. PMID: 33519806 Free PMC article.
Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein.
Delic V, Griffin JWD, Zivkovic S, Zhang Y, Phan TA, Gong H, Chaput D, Reynes C, Dinh VB, Cruz J, Cvitkovic E, Placides D, Frederic E, Mirzaei H, Stevens SM Jr, Jinwal U, Lee DC, Bradshaw PC. Delic V, et al. Neuromolecular Med. 2017 Sep;19(2-3):322-344. doi: 10.1007/s12017-017-8448-8. Epub 2017 Jun 15. Neuromolecular Med. 2017. PMID: 28620826
The days ahead.
Noseworthy E, Gladding M, Wills J, Tindall C, Placides D, Sanford T, Sims L, Marshall D, Jones RM, Bayne D, et al. Noseworthy E, et al. Food Manage. 1991 Jul;26(7):118-20, 122, 124 passim. Food Manage. 1991. PMID: 10112465