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The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.
Bravo-San Pedro JM, Niso-Santano M, Gómez-Sánchez R, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Bravo-San Pedro JM, et al. Cell Mol Life Sci. 2013 Jan;70(1):121-36. doi: 10.1007/s00018-012-1061-y. Epub 2012 Jul 8. Cell Mol Life Sci. 2013. PMID: 22773119
The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.
Bravo-San Pedro JM, Gómez-Sánchez R, Niso-Santano M, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Bravo-San Pedro JM, et al. Autophagy. 2012 Oct;8(10):1537-9. doi: 10.4161/auto.21270. Epub 2012 Aug 23. Autophagy. 2012. PMID: 22914360 Free PMC article.
Parkinson's disease: leucine-rich repeat kinase 2 and autophagy, intimate enemies.
Bravo-San Pedro JM, Gómez-Sánchez R, Pizarro-Estrella E, Niso-Santano M, González-Polo RA, Fuentes Rodríguez JM. Bravo-San Pedro JM, et al. Among authors: pizarro estrella e. Parkinsons Dis. 2012;2012:151039. doi: 10.1155/2012/151039. Epub 2012 Aug 30. Parkinsons Dis. 2012. PMID: 22970411 Free PMC article.
Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression.
Gómez-Sánchez R, Gegg ME, Bravo-San Pedro JM, Niso-Santano M, Alvarez-Erviti L, Pizarro-Estrella E, Gutiérrez-Martín Y, Alvarez-Barrientos A, Fuentes JM, González-Polo RA, Schapira AH. Gómez-Sánchez R, et al. Among authors: pizarro estrella e. Neurobiol Dis. 2014 Feb;62:426-40. doi: 10.1016/j.nbd.2013.10.021. Epub 2013 Oct 29. Neurobiol Dis. 2014. PMID: 24184327 Free PMC article.
G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.
Yakhine-Diop SM, Bravo-San Pedro JM, Gómez-Sánchez R, Pizarro-Estrella E, Rodríguez-Arribas M, Climent V, Aiastui A, López de Munain A, Fuentes JM, González-Polo RA. Yakhine-Diop SM, et al. Among authors: pizarro estrella e. Toxicology. 2014 Oct 3;324:1-9. doi: 10.1016/j.tox.2014.07.001. Epub 2014 Jul 10. Toxicology. 2014. PMID: 25017139
Routine Western blot to check autophagic flux: cautions and recommendations.
Gómez-Sánchez R, Pizarro-Estrella E, Yakhine-Diop SM, Rodríguez-Arribas M, Bravo-San Pedro JM, Fuentes JM, González-Polo RA. Gómez-Sánchez R, et al. Among authors: pizarro estrella e. Anal Biochem. 2015 May 15;477:13-20. doi: 10.1016/j.ab.2015.02.020. Epub 2015 Mar 4. Anal Biochem. 2015. PMID: 25747848
mRNA and protein dataset of autophagy markers (LC3 and p62) in several cell lines.
Gómez-Sánchez R, Yakhine-Diop SM, Rodríguez-Arribas M, Bravo-San Pedro JM, Martínez-Chacón G, Uribe-Carretero E, Pinheiro de Castro DC, Pizarro-Estrella E, Fuentes JM, González-Polo RA. Gómez-Sánchez R, et al. Among authors: pizarro estrella e. Data Brief. 2016 Mar 9;7:641-7. doi: 10.1016/j.dib.2016.02.085. eCollection 2016 Jun. Data Brief. 2016. PMID: 27054171 Free PMC article.
14 results