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Leiodermatolide, a novel marine natural product, has potent cytotoxic and antimitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits antitumor activity.
Guzmán EA, Xu Q, Pitts TP, Mitsuhashi KO, Baker C, Linley PA, Oestreicher J, Tendyke K, Winder PL, Suh EM, Wright AE. Guzmán EA, et al. Among authors: pitts tp. Int J Cancer. 2016 Nov 1;139(9):2116-26. doi: 10.1002/ijc.30253. Epub 2016 Jul 19. Int J Cancer. 2016. PMID: 27376928 Free PMC article.
Early effects of lasonolide a on pancreatic cancer cells.
Isbrucker RA, Guzmán EA, Pitts TP, Wright AE. Isbrucker RA, et al. Among authors: pitts tp. J Pharmacol Exp Ther. 2009 Nov;331(2):733-9. doi: 10.1124/jpet.109.155531. Epub 2009 Aug 19. J Pharmacol Exp Ther. 2009. PMID: 19692635 Free PMC article.
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