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Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma.
Nilsson M, Rhedin M, Hendrickx R, Berglund S, Piras A, Blomgran P, Cavallin A, Collins M, Dahl G, Dekkak B, Ericsson T, Hagberg N, Holmberg AA, Leffler A, Lundqvist AJ, Markou T, Pinkerton J, Rönnblom L, Siu S, Taylor V, Wennberg T, Zervas D, Laurence ADJ, Mitra S, Belvisi MG, Birrell M, Borde A. Nilsson M, et al. Among authors: pinkerton j. Drug Des Devel Ther. 2022 Aug 31;16:2901-2917. doi: 10.2147/DDDT.S354291. eCollection 2022. Drug Des Devel Ther. 2022. PMID: 36068788 Free PMC article.
PI3Kγδ inhibition suppresses key disease features in a rat model of asthma.
Pinkerton JW, Preite S, Piras A, Zervas D, Markou T, Freeman MS, Hofving T, Ivarsson E, Bonvini SJ, Brailsford W, Yrlid L, Belvisi MG, Birrell MA. Pinkerton JW, et al. Respir Res. 2024 Apr 23;25(1):175. doi: 10.1186/s12931-024-02814-1. Respir Res. 2024. PMID: 38654248 Free PMC article.
Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma.
Ali MK, Kim RY, Brown AC, Mayall JR, Karim R, Pinkerton JW, Liu G, Martin KL, Starkey MR, Pillar AL, Donovan C, Pathinayake PS, Carroll OR, Trinder D, Tay HL, Badi YE, Kermani NZ, Guo YK, Aryal R, Mumby S, Pavlidis S, Adcock IM, Weaver J, Xenaki D, Oliver BG, Holliday EG, Foster PS, Wark PA, Johnstone DM, Milward EA, Hansbro PM, Horvat JC. Ali MK, et al. Among authors: pinkerton jw. Eur Respir J. 2020 Apr 23;55(4):1901340. doi: 10.1183/13993003.01340-2019. Print 2020 Apr. Eur Respir J. 2020. PMID: 32184317 Free article.
Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma.
Pinkerton JW, Kim RY, Brown AC, Rae BE, Donovan C, Mayall JR, Carroll OR, Khadem Ali M, Scott HA, Berthon BS, Baines KJ, Starkey MR, Kermani NZ, Guo YK, Robertson AAB, O'Neill LAJ, Adcock IM, Cooper MA, Gibson PG, Wood LG, Hansbro PM, Horvat JC. Pinkerton JW, et al. J Allergy Clin Immunol. 2022 Apr;149(4):1270-1280. doi: 10.1016/j.jaci.2021.10.003. Epub 2021 Oct 19. J Allergy Clin Immunol. 2022. PMID: 34678326
Inflammasomes in COPD and neutrophilic asthma.
Kim RY, Pinkerton JW, Gibson PG, Cooper MA, Horvat JC, Hansbro PM. Kim RY, et al. Thorax. 2015 Dec;70(12):1199-201. doi: 10.1136/thoraxjnl-2014-206736. Epub 2015 Oct 22. Thorax. 2015. PMID: 26493990 No abstract available.
MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.
Kim RY, Horvat JC, Pinkerton JW, Starkey MR, Essilfie AT, Mayall JR, Nair PM, Hansbro NG, Jones B, Haw TJ, Sunkara KP, Nguyen TH, Jarnicki AG, Keely S, Mattes J, Adcock IM, Foster PS, Hansbro PM. Kim RY, et al. Among authors: pinkerton jw. J Allergy Clin Immunol. 2017 Feb;139(2):519-532. doi: 10.1016/j.jaci.2016.04.038. Epub 2016 Jun 10. J Allergy Clin Immunol. 2017. PMID: 27448447 Free article.
Elucidating novel disease mechanisms in severe asthma.
Kim RY, Rae B, Neal R, Donovan C, Pinkerton J, Balachandran L, Starkey MR, Knight DA, Horvat JC, Hansbro PM. Kim RY, et al. Among authors: pinkerton j. Clin Transl Immunology. 2016 Jul 15;5(7):e91. doi: 10.1038/cti.2016.37. eCollection 2016 Jul. Clin Transl Immunology. 2016. PMID: 27525064 Free PMC article. Review.
335 results