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Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL. Krumm BE, et al. Among authors: pinkerton ab. Biochemistry. 2023 Apr 4;62(7):1233-1248. doi: 10.1021/acs.biochem.3c00029. Epub 2023 Mar 14. Biochemistry. 2023. PMID: 36917754
An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
Berneburg I, Peddibhotla S, Heimsch KC, Haeussler K, Maloney P, Gosalia P, Preuss J, Rahbari M, Skorokhod O, Valente E, Ulliers D, Simula LF, Buchholz K, Hedrick MP, Hershberger P, Chung TDY, Jackson MR, Schwarzer E, Rahlfs S, Bode L, Becker K, Pinkerton AB. Berneburg I, et al. Among authors: pinkerton ab. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0210921. doi: 10.1128/aac.02109-21. Epub 2022 Mar 10. Antimicrob Agents Chemother. 2022. PMID: 35266827 Free PMC article.
The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment.
Riva L, Goellner S, Biering SB, Huang CT, Rubanov AN, Haselmann U, Warnes CM, De Jesus PD, Martin-Sancho L, Terskikh AV, Harris E, Pinkerton AB, Bartenschlager R, Chanda SK. Riva L, et al. Among authors: pinkerton ab. J Virol. 2021 Oct 27;95(22):e0099621. doi: 10.1128/JVI.00996-21. Epub 2021 Sep 1. J Virol. 2021. PMID: 34468177 Free PMC article.
Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
Stanford SM, Diaz MA, Ardecky RJ, Zou J, Roosild T, Holmes ZJ, Nguyen TP, Hedrick MP, Rodiles S, Guan A, Grotegut S, Santelli E, Chung TDY, Jackson MR, Bottini N, Pinkerton AB. Stanford SM, et al. Among authors: pinkerton ab. J Med Chem. 2021 May 13;64(9):5645-5653. doi: 10.1021/acs.jmedchem.0c02126. Epub 2021 Apr 29. J Med Chem. 2021. PMID: 33914534 Free PMC article.
Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.
Akiu M, Tsuji T, Sogawa Y, Terayama K, Yokoyama M, Tanaka J, Asano D, Sakurai K, Sergienko E, Sessions EH, Gardell SJ, Pinkerton AB, Nakamura T. Akiu M, et al. Among authors: pinkerton ab. Bioorg Med Chem Lett. 2021 Jul 1;43:128048. doi: 10.1016/j.bmcl.2021.128048. Epub 2021 Apr 19. Bioorg Med Chem Lett. 2021. PMID: 33887438
Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth.
Iizuka S, Quintavalle M, Navarro JC, Gribbin KP, Ardecky RJ, Abelman MM, Ma CT, Sergienko E, Zeng FY, Pass I, Thomas GV, McWeeney SK, Hassig CA, Pinkerton AB, Courtneidge SA. Iizuka S, et al. Among authors: pinkerton ab. Cancer Res. 2021 Mar 15;81(6):1472-1485. doi: 10.1158/0008-5472.CAN-20-2383. Epub 2021 Jan 7. Cancer Res. 2021. PMID: 33414172 Free PMC article.
96 results