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Eugenol disrupts Plasmodium falciparum intracellular development during the erythrocytic cycle and protects against cerebral malaria.
Pontes KAO, Silva LS, Santos EC, Pinheiro AS, Teixeira DE, Peruchetti DB, Silva-Aguiar RP, Wendt CHC, Miranda KR, Coelho-de-Souza AN, Leal-Cardoso JH, Caruso-Neves C, Pinheiro AAS. Pontes KAO, et al. Among authors: pinheiro as, pinheiro aas. Biochim Biophys Acta Gen Subj. 2021 Mar;1865(3):129813. doi: 10.1016/j.bbagen.2020.129813. Epub 2020 Dec 13. Biochim Biophys Acta Gen Subj. 2021. PMID: 33321150
The monoterpene 1,8-cineole prevents cerebral edema in a murine model of severe malaria.
Santos ECD, Silva LS, Pinheiro AS, Teixeira DE, Peruchetti DB, Silva-Aguiar RP, Wendt CHC, Miranda KR, Coelho-de-Souza AN, Leal-Cardoso JH, Caruso-Neves C, Pinheiro AAS. Santos ECD, et al. Among authors: pinheiro as, pinheiro aas. PLoS One. 2022 May 12;17(5):e0268347. doi: 10.1371/journal.pone.0268347. eCollection 2022. PLoS One. 2022. PMID: 35550638 Free PMC article.
Kinins Released by Erythrocytic Stages of Plasmodium falciparum Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors.
Silva LS, Pinheiro AS, Teixeira DE, Silva-Aguiar RP, Peruchetti DB, Scharfstein J, Caruso-Neves C, Pinheiro AAS. Silva LS, et al. Among authors: pinheiro as, pinheiro aas. Front Med (Lausanne). 2019 Apr 16;6:75. doi: 10.3389/fmed.2019.00075. eCollection 2019. Front Med (Lausanne). 2019. PMID: 31058153 Free PMC article.
Copper drives prion protein phase separation and modulates aggregation.
do Amaral MJ, Mohapatra S, Passos AR, Lopes da Silva TS, Carvalho RS, da Silva Almeida M, Pinheiro AS, Wegmann S, Cordeiro Y. do Amaral MJ, et al. Among authors: pinheiro as. Sci Adv. 2023 Nov 3;9(44):eadi7347. doi: 10.1126/sciadv.adi7347. Epub 2023 Nov 3. Sci Adv. 2023. PMID: 37922348 Free PMC article.
Is there a role for bradykinin in cerebral malaria pathogenesis?
Pinheiro AS, Kazura JW, Pinheiro AA, Schmaier AH. Pinheiro AS, et al. Front Cell Infect Microbiol. 2023 Aug 10;13:1184896. doi: 10.3389/fcimb.2023.1184896. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37637466 Free PMC article. Review.
Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development.
Berg H, Wirtz Martin MA, Altincekic N, Alshamleh I, Kaur Bains J, Blechar J, Ceylan B, de Jesus V, Dhamotharan K, Fuks C, Gande SL, Hargittay B, Hohmann KF, Hutchison MT, Marianne Korn S, Krishnathas R, Kutz F, Linhard V, Matzel T, Meiser N, Niesteruk A, Pyper DJ, Schulte L, Trucks S, Azzaoui K, Blommers MJJ, Gadiya Y, Karki R, Zaliani A, Gribbon P, da Silva Almeida M, Dinis Anobom C, Bula AL, Bütikofer M, Putinhon Caruso Í, Caterina Felli I, Da Poian AT, Cardoso de Amorim G, Fourkiotis NK, Gallo A, Ghosh D, Gomes-Neto F, Gorbatyuk O, Hao B, Kurauskas V, Lecoq L, Li Y, Cunha Mebus-Antunes N, Mompeán M, Cristtina Neves-Martins T, Ninot-Pedrosa M, Pinheiro AS, Pontoriero L, Pustovalova Y, Riek R, Robertson AJ, Jose Abi Saad M, Treviño MÁ, Tsika AC, Almeida FCL, Bax A, Henzler-Wildman K, Hoch JC, Jaudzems K, Laurents DV, Orts J, Pierattelli R, Spyroulias GA, Duchardt-Ferner E, Ferner J, Fürtig B, Hengesbach M, Löhr F, Qureshi N, Richter C, Saxena K, Schlundt A, Sreeramulu S, Wacker A, Weigand JE, Wirmer-Bartoschek J, Wöhnert J, Schwalbe H. Berg H, et al. Among authors: pinheiro as. Angew Chem Int Ed Engl. 2022 Nov 14;61(46):e202205858. doi: 10.1002/anie.202205858. Epub 2022 Oct 13. Angew Chem Int Ed Engl. 2022. PMID: 36115062 Free PMC article.
56 results