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Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.
Wijeyewickrema LC, Lameignere E, Hor L, Duncan RC, Shiba T, Travers RJ, Kapopara PR, Lei V, Smith SA, Kim H, Morrissey JH, Pike RN, Conway EM. Wijeyewickrema LC, et al. Among authors: pike rn. Blood. 2016 Sep 29;128(13):1766-76. doi: 10.1182/blood-2016-02-699561. Epub 2016 Jun 23. Blood. 2016. PMID: 27338096 Free PMC article.
Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor.
Kerr FK, Thomas AR, Wijeyewickrema LC, Whisstock JC, Boyd SE, Kaiserman D, Matthews AY, Bird PI, Thielens NM, Rossi V, Pike RN. Kerr FK, et al. Among authors: pike rn. Mol Immunol. 2008 Feb;45(3):670-7. doi: 10.1016/j.molimm.2007.07.008. Epub 2007 Aug 20. Mol Immunol. 2008. PMID: 17709141
A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites.
Beckham SA, Piedrafita D, Phillips CI, Samarawickrema N, Law RH, Smooker PM, Quinsey NS, Irving JA, Greenwood D, Verhelst SH, Bogyo M, Turk B, Coetzer TH, Wijeyewickrema LC, Spithill TW, Pike RN. Beckham SA, et al. Among authors: pike rn. Int J Biochem Cell Biol. 2009 Jul;41(7):1601-12. doi: 10.1016/j.biocel.2009.02.003. Epub 2009 Feb 20. Int J Biochem Cell Biol. 2009. PMID: 19401154 Free PMC article.
The effects of exosite occupancy on the substrate specificity of thrombin.
Ng NM, Quinsey NS, Matthews AY, Kaiserman D, Wijeyewickrema LC, Bird PI, Thompson PE, Pike RN. Ng NM, et al. Among authors: pike rn. Arch Biochem Biophys. 2009 Sep;489(1-2):48-54. doi: 10.1016/j.abb.2009.07.012. Epub 2009 Jul 26. Arch Biochem Biophys. 2009. PMID: 19638274
165 results