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Page 1
Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.
Weber T, Potthoff J, Bizu S, Labuhn M, Dold L, Schoofs T, Horning M, Ercanoglu MS, Kreer C, Gieselmann L, Vanshylla K, Langhans B, Janicki H, Ströh LJ, Knops E, Nierhoff D, Spengler U, Kaiser R, Bjorkman PJ, Krey T, Bankwitz D, Pfeifer N, Pietschmann T, Flyak AI, Klein F. Weber T, et al. Among authors: pietschmann t. Immunity. 2022 Feb 8;55(2):341-354.e7. doi: 10.1016/j.immuni.2021.12.003. Epub 2022 Jan 5. Immunity. 2022. PMID: 34990590 Free PMC article.
Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes.
Bankwitz D, Steinmann E, Bitzegeio J, Ciesek S, Friesland M, Herrmann E, Zeisel MB, Baumert TF, Keck ZY, Foung SK, Pécheur EI, Pietschmann T. Bankwitz D, et al. Among authors: pietschmann t. J Virol. 2010 Jun;84(11):5751-63. doi: 10.1128/JVI.02200-09. Epub 2010 Mar 31. J Virol. 2010. PMID: 20357091 Free PMC article.
Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope.
Ruhl M, Chhatwal P, Strathmann H, Kuntzen T, Bankwitz D, Skibbe K, Walker A, Heinemann FM, Horn PA, Allen TM, Hoffmann D, Pietschmann T, Timm J. Ruhl M, et al. Among authors: pietschmann t. J Virol. 2012 Jan;86(2):991-1000. doi: 10.1128/JVI.05603-11. Epub 2011 Nov 9. J Virol. 2012. PMID: 22072759 Free PMC article.
A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.
Haid S, Novodomská A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Poenisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg AR, Wong-Staal F, Davioud-Charvet E, Pietschmann T. Haid S, et al. Among authors: pietschmann t. Gastroenterology. 2012 Jul;143(1):213-22.e5. doi: 10.1053/j.gastro.2012.03.036. Epub 2012 Mar 27. Gastroenterology. 2012. PMID: 22465429 Free article.
Bile acids specifically increase hepatitis C virus RNA-replication.
Chhatwal P, Bankwitz D, Gentzsch J, Frentzen A, Schult P, Lohmann V, Pietschmann T. Chhatwal P, et al. Among authors: pietschmann t. PLoS One. 2012;7(4):e36029. doi: 10.1371/journal.pone.0036029. Epub 2012 Apr 25. PLoS One. 2012. PMID: 22558311 Free PMC article.
Characterization of the inhibition of hepatitis C virus entry by in vitro-generated and patient-derived oxidized low-density lipoprotein.
Westhaus S, Bankwitz D, Ernst S, Rohrmann K, Wappler I, Agné C, Luchtefeld M, Schieffer B, Sarrazin C, Manns MP, Pietschmann T, Ciesek S, von Hahn T. Westhaus S, et al. Among authors: pietschmann t. Hepatology. 2013 May;57(5):1716-24. doi: 10.1002/hep.26190. Epub 2013 Feb 15. Hepatology. 2013. PMID: 23212706 Free article.
Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly.
Hueging K, Doepke M, Vieyres G, Bankwitz D, Frentzen A, Doerrbecker J, Gumz F, Haid S, Wölk B, Kaderali L, Pietschmann T. Hueging K, et al. Among authors: pietschmann t. J Virol. 2014 Feb;88(3):1433-46. doi: 10.1128/JVI.01815-13. Epub 2013 Oct 30. J Virol. 2014. PMID: 24173232 Free PMC article.
Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents.
Vercauteren K, Van Den Eede N, Mesalam AA, Belouzard S, Catanese MT, Bankwitz D, Wong-Staal F, Cortese R, Dubuisson J, Rice CM, Pietschmann T, Leroux-Roels G, Nicosia A, Meuleman P. Vercauteren K, et al. Among authors: pietschmann t. Hepatology. 2014 Nov;60(5):1508-18. doi: 10.1002/hep.27196. Epub 2014 Jul 30. Hepatology. 2014. PMID: 24797654 Free PMC article.
211 results