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Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas.
Kuburich NA, den Hollander P, Castaneda M, Pietilä M, Tang X, Batra H, Martínez-Peña F, Visal TH, Zhou T, Demestichas BR, Dontula RV, Liu JY, Maddela JJ, Padmanabhan RS, Phi LTH, Rosolen MJ, Sabapathy T, Kumar D, Giancotti FG, Lairson LL, Raso MG, Soundararajan R, Mani SA. Kuburich NA, et al. Among authors: pietila m. Cell Rep. 2023 Dec 26;42(12):113470. doi: 10.1016/j.celrep.2023.113470. Epub 2023 Nov 20. Cell Rep. 2023. PMID: 37979166 Free PMC article.
A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.
Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. Bollong MJ, et al. Among authors: pietila m. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. doi: 10.1073/pnas.1716009114. Epub 2017 Oct 30. Proc Natl Acad Sci U S A. 2017. PMID: 29087350 Free PMC article.
GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer.
Vijay GV, Zhao N, Den Hollander P, Toneff MJ, Joseph R, Pietila M, Taube JH, Sarkar TR, Ramirez-Pena E, Werden SJ, Shariati M, Gao R, Sobieski M, Stephan CC, Sphyris N, Miura N, Davies P, Chang JT, Soundararajan R, Rosen JM, Mani SA. Vijay GV, et al. Among authors: pietila m. Breast Cancer Res. 2019 Mar 7;21(1):37. doi: 10.1186/s13058-019-1125-0. Breast Cancer Res. 2019. PMID: 30845991 Free PMC article.
HIF-1α is upregulated in human mesenchymal stem cells.
Palomäki S, Pietilä M, Laitinen S, Pesälä J, Sormunen R, Lehenkari P, Koivunen P. Palomäki S, et al. Among authors: pietila m. Stem Cells. 2013 Sep;31(9):1902-9. doi: 10.1002/stem.1435. Stem Cells. 2013. PMID: 23744828
190 results