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146 results

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Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.
Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Garris CS, et al. Among authors: pierce rh. Immunity. 2018 Dec 18;49(6):1148-1161.e7. doi: 10.1016/j.immuni.2018.09.024. Epub 2018 Dec 11. Immunity. 2018. PMID: 30552023 Free PMC article.
Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma.
Algazi AP, Twitty CG, Tsai KK, Le M, Pierce R, Browning E, Hermiz R, Canton DA, Bannavong D, Oglesby A, Francisco M, Fong L, Pittet MJ, Arlauckas SP, Garris C, Levine LP, Bifulco C, Ballesteros-Merino C, Bhatia S, Gargosky S, Andtbacka RHI, Fox BA, Rosenblum MD, Daud AI. Algazi AP, et al. Clin Cancer Res. 2020 Jun 15;26(12):2827-2837. doi: 10.1158/1078-0432.CCR-19-2217. Epub 2020 May 6. Clin Cancer Res. 2020. PMID: 32376655 Free PMC article. Clinical Trial.
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.
Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Garris CS, et al. Among authors: pierce rh. Immunity. 2022 Sep 13;55(9):1749. doi: 10.1016/j.immuni.2022.07.021. Immunity. 2022. PMID: 36103861 No abstract available.
In-situ tumor vaccination: Bringing the fight to the tumor.
Pierce RH, Campbell JS, Pai SI, Brody JD, Kohrt HE. Pierce RH, et al. Hum Vaccin Immunother. 2015;11(8):1901-9. doi: 10.1080/21645515.2015.1049779. Hum Vaccin Immunother. 2015. PMID: 26055074 Free PMC article. Review.
Intratumoral Plasmid IL12 Electroporation Therapy in Patients with Advanced Melanoma Induces Systemic and Intratumoral T-cell Responses.
Greaney SK, Algazi AP, Tsai KK, Takamura KT, Chen L, Twitty CG, Zhang L, Paciorek A, Pierce RH, Le MH, Daud AI, Fong L. Greaney SK, et al. Among authors: pierce rh. Cancer Immunol Res. 2020 Feb;8(2):246-254. doi: 10.1158/2326-6066.CIR-19-0359. Epub 2019 Dec 18. Cancer Immunol Res. 2020. PMID: 31852717 Free PMC article. Clinical Trial.
Intratumoral delivery of an HPV vaccine elicits a broad anti-tumor immune response that translates into a potent anti-tumor effect in a preclinical murine HPV model.
Ishida E, Lee J, Campbell JS, Chakravarty PD, Katori Y, Ogawa T, Johnson L, Mukhopadhyay A, Faquin WC, Lin DT, Wirth LJ, Pierce RH, Pai SI. Ishida E, et al. Among authors: pierce rh. Cancer Immunol Immunother. 2019 Aug;68(8):1273-1286. doi: 10.1007/s00262-019-02357-1. Epub 2019 Jun 26. Cancer Immunol Immunother. 2019. PMID: 31243491 Free PMC article.
Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma.
Bhatia S, Longino NV, Miller NJ, Kulikauskas R, Iyer JG, Ibrani D, Blom A, Byrd DR, Parvathaneni U, Twitty CG, Campbell JS, Le MH, Gargosky S, Pierce RH, Heller R, Daud AI, Nghiem P. Bhatia S, et al. Among authors: pierce rh. Clin Cancer Res. 2020 Feb 1;26(3):598-607. doi: 10.1158/1078-0432.CCR-19-0972. Epub 2019 Oct 3. Clin Cancer Res. 2020. PMID: 31582519 Free PMC article.
The Liver-Immunity Nexus and Cancer Immunotherapy.
Lee JC, Green MD, Huppert LA, Chow C, Pierce RH, Daud AI. Lee JC, et al. Among authors: pierce rh. Clin Cancer Res. 2022 Jan 1;28(1):5-12. doi: 10.1158/1078-0432.CCR-21-1193. Epub 2021 Jul 20. Clin Cancer Res. 2022. PMID: 34285059 Free PMC article. Review.
Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy.
Telli ML, Nagata H, Wapnir I, Acharya CR, Zablotsky K, Fox BA, Bifulco CB, Jensen SM, Ballesteros-Merino C, Le MH, Pierce RH, Browning E, Hermiz R, Svenson L, Bannavong D, Jaffe K, Sell J, Foerter KM, Canton DA, Twitty CG, Osada T, Lyerly HK, Crosby EJ. Telli ML, et al. Among authors: pierce rh. Clin Cancer Res. 2021 May 1;27(9):2481-2493. doi: 10.1158/1078-0432.CCR-20-3944. Epub 2021 Feb 16. Clin Cancer Res. 2021. PMID: 33593880 Free PMC article. Clinical Trial.
146 results