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Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
Fracchiolla G, Lavecchia A, Laghezza A, Piemontese L, Trisolini R, Carbonara G, Tortorella P, Novellino E, Loiodice F. Fracchiolla G, et al. Among authors: piemontese l. Bioorg Med Chem. 2008 Nov 1;16(21):9498-510. doi: 10.1016/j.bmc.2008.09.045. Epub 2008 Sep 19. Bioorg Med Chem. 2008. PMID: 18835719
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
Fracchiolla G, Laghezza A, Piemontese L, Tortorella P, Mazza F, Montanari R, Pochetti G, Lavecchia A, Novellino E, Pierno S, Conte Camerino D, Loiodice F. Fracchiolla G, et al. Among authors: piemontese l. J Med Chem. 2009 Oct 22;52(20):6382-93. doi: 10.1021/jm900941b. J Med Chem. 2009. PMID: 19775169
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand-macromolecule interaction.
Calleri E, Fracchiolla G, Montanari R, Pochetti G, Lavecchia A, Loiodice F, Laghezza A, Piemontese L, Massolini G, Temporini C. Calleri E, et al. Among authors: piemontese l. J Chromatogr A. 2012 Apr 6;1232:84-92. doi: 10.1016/j.chroma.2011.10.037. Epub 2011 Oct 19. J Chromatogr A. 2012. PMID: 22056242
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Porcelli L, Gilardi F, Laghezza A, Piemontese L, Mitro N, Azzariti A, Altieri F, Cervoni L, Fracchiolla G, Giudici M, Guerrini U, Lavecchia A, Montanari R, Di Giovanni C, Paradiso A, Pochetti G, Simone GM, Tortorella P, Crestani M, Loiodice F. Porcelli L, et al. Among authors: piemontese l. J Med Chem. 2012 Jan 12;55(1):37-54. doi: 10.1021/jm201306q. Epub 2011 Dec 2. J Med Chem. 2012. PMID: 22081932
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
Fracchiolla G, Laghezza A, Piemontese L, Parente M, Lavecchia A, Pochetti G, Montanari R, Di Giovanni C, Carbonara G, Tortorella P, Novellino E, Loiodice F. Fracchiolla G, et al. Among authors: piemontese l. Bioorg Med Chem. 2012 Mar 15;20(6):2141-51. doi: 10.1016/j.bmc.2012.01.025. Epub 2012 Jan 28. Bioorg Med Chem. 2012. PMID: 22341573
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.
Laghezza A, Pochetti G, Lavecchia A, Fracchiolla G, Faliti S, Piemontese L, Di Giovanni C, Iacobazzi V, Infantino V, Montanari R, Capelli D, Tortorella P, Loiodice F. Laghezza A, et al. Among authors: piemontese l. J Med Chem. 2013 Jan 10;56(1):60-72. doi: 10.1021/jm301018z. Epub 2012 Dec 18. J Med Chem. 2013. PMID: 23171045
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection.
Temporini C, Pochetti G, Fracchiolla G, Piemontese L, Montanari R, Moaddel R, Laghezza A, Altieri F, Cervoni L, Ubiali D, Prada E, Loiodice F, Massolini G, Calleri E. Temporini C, et al. Among authors: piemontese l. J Chromatogr A. 2013 Apr 5;1284:36-43. doi: 10.1016/j.chroma.2013.01.077. Epub 2013 Feb 16. J Chromatogr A. 2013. PMID: 23466198 Free PMC article.
264 results