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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models.
Chocron ES, Munkácsy E, Kim HS, Karpowicz P, Jiang N, Van Skike CE, DeRosa N, Banh AQ, Palavicini JP, Wityk P, Kalinowski L, Galvan V, Osmulski PA, Jankowska E, Gaczynska M, Pickering AM. Chocron ES, et al. Among authors: pickering am. Sci Adv. 2022 Jun 10;8(23):eabk2252. doi: 10.1126/sciadv.abk2252. Epub 2022 Jun 8. Sci Adv. 2022. PMID: 35675410 Free PMC article.
Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours.
Zhu Z, Achreja A, Meurs N, Animasahun O, Owen S, Mittal A, Parikh P, Lo TW, Franco-Barraza J, Shi J, Gunchick V, Sherman MH, Cukierman E, Pickering AM, Maitra A, Sahai V, Morgan MA, Nagrath S, Lawrence TS, Nagrath D. Zhu Z, et al. Among authors: pickering am. Nat Metab. 2020 Aug;2(8):775-792. doi: 10.1038/s42255-020-0226-5. Epub 2020 Jul 6. Nat Metab. 2020. PMID: 32694827 Free PMC article.
New Peptide-Based Pharmacophore Activates 20S Proteasome.
Osmulski PA, Karpowicz P, Jankowska E, Bohmann J, Pickering AM, Gaczyńska M. Osmulski PA, et al. Among authors: pickering am. Molecules. 2020 Mar 22;25(6):1439. doi: 10.3390/molecules25061439. Molecules. 2020. PMID: 32235805 Free PMC article.
23 results