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Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.
Hezaveh K, Shinde RS, Klötgen A, Halaby MJ, Lamorte S, Ciudad MT, Quevedo R, Neufeld L, Liu ZQ, Jin R, Grünwald BT, Foerster EG, Chaharlangi D, Guo M, Makhijani P, Zhang X, Pugh TJ, Pinto DM, Co IL, McGuigan AP, Jang GH, Khokha R, Ohashi PS, O'Kane GM, Gallinger S, Navarre WW, Maughan H, Philpott DJ, Brooks DG, McGaha TL. Hezaveh K, et al. Among authors: philpott dj. Immunity. 2022 Feb 8;55(2):324-340.e8. doi: 10.1016/j.immuni.2022.01.006. Immunity. 2022. PMID: 35139353 Free PMC article.
Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.
Belcheva A, Irrazabal T, Robertson SJ, Streutker C, Maughan H, Rubino S, Moriyama EH, Copeland JK, Surendra A, Kumar S, Green B, Geddes K, Pezo RC, Navarre WW, Milosevic M, Wilson BC, Girardin SE, Wolever TMS, Edelmann W, Guttman DS, Philpott DJ, Martin A. Belcheva A, et al. Among authors: philpott dj. Cell. 2014 Jul 17;158(2):288-299. doi: 10.1016/j.cell.2014.04.051. Cell. 2014. PMID: 25036629 Free article.
The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition.
Lemire P, Robertson SJ, Maughan H, Tattoli I, Streutker CJ, Platnich JM, Muruve DA, Philpott DJ, Girardin SE. Lemire P, et al. Among authors: philpott dj. Cell Rep. 2017 Dec 26;21(13):3653-3661. doi: 10.1016/j.celrep.2017.12.026. Cell Rep. 2017. PMID: 29281815 Free article.
Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria.
Sorbara MT, Foerster EG, Tsalikis J, Abdel-Nour M, Mangiapane J, Sirluck-Schroeder I, Tattoli I, van Dalen R, Isenman DE, Rohde JR, Girardin SE, Philpott DJ. Sorbara MT, et al. Among authors: philpott dj. Cell Host Microbe. 2018 May 9;23(5):644-652.e5. doi: 10.1016/j.chom.2018.04.008. Cell Host Microbe. 2018. PMID: 29746835 Free article.
NOD1 and NOD2 in inflammation, immunity and disease.
Mukherjee T, Hovingh ES, Foerster EG, Abdel-Nour M, Philpott DJ, Girardin SE. Mukherjee T, et al. Among authors: philpott dj. Arch Biochem Biophys. 2019 Jul 30;670:69-81. doi: 10.1016/j.abb.2018.12.022. Epub 2018 Dec 19. Arch Biochem Biophys. 2019. PMID: 30578751 Review.
Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells.
Maisonneuve C, Tsang DKL, Foerster EG, Robert LM, Mukherjee T, Prescott D, Tattoli I, Lemire P, Winer DA, Winer S, Streutker CJ, Geddes K, Cadwell K, Ferrero RL, Martin A, Girardin SE, Philpott DJ. Maisonneuve C, et al. Among authors: philpott dj. Cell Rep. 2021 Jan 26;34(4):108677. doi: 10.1016/j.celrep.2020.108677. Cell Rep. 2021. PMID: 33503439 Free article.
How autophagy controls the intestinal epithelial barrier.
Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE, Philpott DJ. Foerster EG, et al. Among authors: philpott dj. Autophagy. 2022 Jan;18(1):86-103. doi: 10.1080/15548627.2021.1909406. Epub 2021 Apr 27. Autophagy. 2022. PMID: 33906557 Free PMC article. Review.
241 results