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Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake.
Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, López-Giráldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Sayal BS, González Zapata S, Dann P, Brown SN, Hirabara S, Vatner DF, Goedeke L, Philbrick W, Shulman GI, Bogan JS. Habtemichael EN, et al. Among authors: philbrick w. Nat Metab. 2021 Mar;3(3):378-393. doi: 10.1038/s42255-021-00359-x. Epub 2021 Mar 8. Nat Metab. 2021. PMID: 33686286 Free PMC article.
Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle.
Löffler MG, Birkenfeld AL, Philbrick KM, Belman JP, Habtemichael EN, Booth CJ, Castorena CM, Choi CS, Jornayvaz FR, Gassaway BM, Lee HY, Cartee GD, Philbrick W, Shulman GI, Samuel VT, Bogan JS. Löffler MG, et al. Among authors: philbrick km, philbrick w. J Biol Chem. 2013 Jul 12;288(28):20135-50. doi: 10.1074/jbc.M113.458075. Epub 2013 Jun 6. J Biol Chem. 2013. PMID: 23744065 Free PMC article.
Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos.
Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. Jesinkey SR, et al. Among authors: philbrick wm. Cell Rep. 2019 Jul 16;28(3):759-772.e10. doi: 10.1016/j.celrep.2019.06.058. Cell Rep. 2019. PMID: 31315053 Free PMC article.
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance.
Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, Shulman GI. Petersen MC, et al. Among authors: philbrick w. J Clin Invest. 2016 Nov 1;126(11):4361-4371. doi: 10.1172/JCI86013. Epub 2016 Oct 17. J Clin Invest. 2016. PMID: 27760050 Free PMC article.
73 results