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Tailoring treatment of haemophilia B: accounting for the distribution and clearance of standard and extended half-life FIX concentrates.
Iorio A, Fischer K, Blanchette V, Rangarajan S, Young G, Morfini M; Pharmacokinetic (PK) Expert Working Group of the International Prophylaxis Study Group (the IPSG). Iorio A, et al. Thromb Haemost. 2017 Jun 2;117(6):1023-1030. doi: 10.1160/TH16-12-0942. Epub 2017 Mar 30. Thromb Haemost. 2017. PMID: 28357444 Review.
The recent introduction of extended half-life recombinant FIX molecules (EHL-rFIX), has prompted a thorough reassessment of the clinical efficacy, PK and pharmacodynamics of plasma-derived and recombinant FIX. First, using longer sampling times and multi-compartmental P …
The recent introduction of extended half-life recombinant FIX molecules (EHL-rFIX), has prompted a thorough reassessment of the clinical eff …
Terminal half-life of FVIII and FIX according to age, blood group and concentrate type: Data from the WAPPS database.
Versloot O, Iserman E, Chelle P, Germini F, Edginton AN, Schutgens REG, Iorio A, Fischer K; Pharmacokinetic (PK) Expert Working Group of the International Prophylaxis Study Group (IPSG). Versloot O, et al. J Thromb Haemost. 2021 Aug;19(8):1896-1906. doi: 10.1111/jth.15395. Epub 2021 Jun 18. J Thromb Haemost. 2021. PMID: 34013558 Free PMC article.
BACKGROUND: Real-life data on pharmacokinetics of factor (F) VIII/IX concentrates, especially extended half-life (EHL), concentrates in large cohorts of persons with hemophilia are currently lacking. OBJECTIVES: This cross-sectional study aimed to establish reference value …
BACKGROUND: Real-life data on pharmacokinetics of factor (F) VIII/IX concentrates, especially extended half-life (EHL), concentrates in larg …