Pfuhler S - Search Results

1

Pyrrolizidine alkaloids in food and phytomedicine: Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review.

Schrenk D, Gao L, Lin G, Mahony C, Mulder PPJ, Peijnenburg A, Pfuhler S, Rietjens IMCM, Rutz L, Steinhoff B, These A. Schrenk D, et al. Among authors: pfuhler s. Food Chem Toxicol. 2020 Feb;136:111107. doi: 10.1016/j.fct.2019.111107. Epub 2020 Jan 3. Food Chem Toxicol. 2020. PMID: 31904473 Review.

2

Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells.

Allemang A, Mahony C, Lester C, Pfuhler S. Allemang A, et al. Among authors: pfuhler s. Food Chem Toxicol. 2018 Nov;121:72-81. doi: 10.1016/j.fct.2018.08.003. Epub 2018 Aug 17. Food Chem Toxicol. 2018. PMID: 30125636

3

Threshold of toxicological concern (TTC) for botanicals - Concentration data analysis of potentially genotoxic constituents to substantiate and extend the TTC approach to botanicals.

Mahony C, Bowtell P, Huber M, Kosemund K, Pfuhler S, Zhu T, Barlow S, McMillan DA. Mahony C, et al. Among authors: pfuhler s. Food Chem Toxicol. 2020 Apr;138:111182. doi: 10.1016/j.fct.2020.111182. Epub 2020 Feb 10. Food Chem Toxicol. 2020. PMID: 32058013

4

A genotoxicity assessment approach for botanical materials demonstrated with Poria cocos.

Sun B, Huang B, Sica VP, Baker TR, Pfuhler S. Sun B, et al. Among authors: pfuhler s. Food Chem Toxicol. 2021 Oct;156:112521. doi: 10.1016/j.fct.2021.112521. Epub 2021 Aug 27. Food Chem Toxicol. 2021. PMID: 34461192 Review.

5

Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment-A Workshop Report.

Schrenk D, Fahrer J, Allemang A, Fu P, Lin G, Mahony C, Mulder PPJ, Peijnenburg A, Pfuhler S, Rietjens IMCM, Sachse B, Steinhoff B, These A, Troutman J, Wiesner J. Schrenk D, et al. Among authors: pfuhler s. Planta Med. 2022 Feb;88(2):98-117. doi: 10.1055/a-1646-3618. Epub 2021 Oct 29. Planta Med. 2022. PMID: 34715696 Free article.

6

Assessing the genotoxicity and carcinogenicity of 2-chloroethanol through structure activity relationships and in vitro testing approaches.

Allemang A, Lester C, Roth T, Pfuhler S, Peuschel H, Kosemund K, Mahony C, Bergeland T, O'Keeffe L. Allemang A, et al. Among authors: pfuhler s. Food Chem Toxicol. 2022 Oct;168:113290. doi: 10.1016/j.fct.2022.113290. Epub 2022 Jul 19. Food Chem Toxicol. 2022. PMID: 35863484 Free article. Review.

7

The in vitro genotoxicity potency of mixtures of pyrrolizidine alkaloids can be explained by dose addition of the individual mixture components.

Allemang A, Mahony C, Pfuhler S. Allemang A, et al. Among authors: pfuhler s. Environ Mol Mutagen. 2022 Dec;63(8-9):400-407. doi: 10.1002/em.22512. Epub 2022 Nov 1. Environ Mol Mutagen. 2022. PMID: 36258291

8

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

Adler S, Basketter D, Creton S, Pelkonen O, van Benthem J, Zuang V, Andersen KE, Angers-Loustau A, Aptula A, Bal-Price A, Benfenati E, Bernauer U, Bessems J, Bois FY, Boobis A, Brandon E, Bremer S, Broschard T, Casati S, Coecke S, Corvi R, Cronin M, Daston G, Dekant W, Felter S, Grignard E, Gundert-Remy U, Heinonen T, Kimber I, Kleinjans J, Komulainen H, Kreiling R, Kreysa J, Leite SB, Loizou G, Maxwell G, Mazzatorta P, Munn S, Pfuhler S, Phrakonkham P, Piersma A, Poth A, Prieto P, Repetto G, Rogiers V, Schoeters G, Schwarz M, Serafimova R, Tähti H, Testai E, van Delft J, van Loveren H, Vinken M, Worth A, Zaldivar JM. Adler S, et al. Among authors: pfuhler s. Arch Toxicol. 2011 May;85(5):367-485. doi: 10.1007/s00204-011-0693-2. Epub 2011 May 1. Arch Toxicol. 2011. PMID: 21533817 Review.

9

The Cosmetics Europe strategy for animal-free genotoxicity testing: project status up-date.

Pfuhler S, Fautz R, Ouedraogo G, Latil A, Kenny J, Moore C, Diembeck W, Hewitt NJ, Reisinger K, Barroso J. Pfuhler S, et al. Toxicol In Vitro. 2014 Feb;28(1):18-23. doi: 10.1016/j.tiv.2013.06.004. Epub 2013 Jun 27. Toxicol In Vitro. 2014. PMID: 23811264 Free article.

10

Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing.

Guérard M, Baum M, Bitsch A, Eisenbrand G, Elhajouji A, Epe B, Habermeyer M, Kaina B, Martus HJ, Pfuhler S, Schmitz C, Sutter A, Thomas AD, Ziemann C, Froetschl R. Guérard M, et al. Among authors: pfuhler s. Mutat Res Rev Mutat Res. 2015 Jan-Mar;763:181-201. doi: 10.1016/j.mrrev.2014.11.001. Epub 2014 Nov 11. Mutat Res Rev Mutat Res. 2015. PMID: 25795120 Review.

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